Abstract
Previous investigations have suggested that initial retinal damage from chloroquine toxicity occurs in ganglion cells, and other ocular tissues are affected only later on. The aim of this study was to evaluate retinal nerve fibre layer (RNFL) thickness measurements, as assessed by scanning laser polarimetry, in a group of patients under long-term treatment with chloroquine. This case-control study included 34 patients using chloroquine diphosphate and 34 age-matched healthy subjects with no previous history of chloroquine intake. All subjects underwent RNFL assessment using the GDx -- Nerve Fibre Analyser (software v.2.0.01). One eye of each patient was randomly selected for statistical analysis. Peripapillary RNFL measurements were compared between the two groups. For patients using chloroquine, the correlation between RNFL measurements and chloroquine dosage was assessed. Mean +/- SD RNFL thickness for patients using chloroquine was 60.6 +/- 11.2 microm, 65.6 +/- 13.2 microm, 74.8 +/- 14.8 microm, 36.2 +/- 9.6 microm and 43.8 +/- 7.9 microm for global, superior, inferior, temporal and nasal regions, respectively. In the control group, the corresponding values were 72.1 +/- 12.7 microm, 79.9 +/- 14.8 microm, 88.3 +/- 14.0 micr...Continue Reading
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