PMID: 9163544Apr 25, 1997Paper

Retinal neurones containing kainate receptors are influenced by exogenous kainate and ischaemia while neurones lacking these receptors are not -- melatonin counteracts the effects of ischaemia and kainate

Brain Research
C Cazevieille, N N Osborne

Abstract

The present experiments were carried out on three types of neurone in primary rabbit retinal cultures. One cell-type, bipolar neurones, have glutamate APB-type metabotropic receptors and can be identified by the presence of thetaPKC-immunoreactivity. The other two cell-types are primarily amacrine cells and can be 'stained' for the localisation of GABA immunoreactivity or for serotonin taken up from the medium. Most of the serotonin-accumulating and GABA-containing neurones contain glutamate kainate-type receptors. Exposure of the cultures to treatment of kainate (50 microM) or experimental ischaemia (8 h followed by 16 h reoxygenation) produced essentially similar findings. The serotonin-accumulating and GABA cells were affected as they were drastically reduced in numbers while the numbers of thetaPKC-containing cells were unaffected. Inclusion of the kainate/AMPA antagonist CNQX (100 microM) or melatonin (100 microM) to the medium during kainate or ischaemia treatments largely prevented the detrimental influences on the serotonin-accumulating and GABA cells. It is concluded that during experimental ischaemia excessive glutamate is released to influence cells which contain kainate and APB-type receptors. However, only the neur...Continue Reading

Citations

Oct 28, 1999·Current Opinion in Ophthalmology·N N OsborneJ P Wood
Apr 17, 2001·Neuroreport·F Q LiangJ Bennett
Mar 10, 2004·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Olivier PayetAgnès Muller
Oct 8, 2005·Korean Journal of Ophthalmology : KJO·Yong Seop HanJi Myeong Yu
Aug 18, 2009·Journal of Neurochemistry·Diego C FernandezRuth E Rosenstein
Oct 19, 2004·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K-G SchmidtN N Osborne
Mar 17, 2018·Scientific Reports·Berkeley K FahrentholdRichard T Libby
Nov 18, 1998·Journal of Neuroscience Research·D X TanG H El-Sokkary
Jun 10, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E GiladC Szabó
Sep 24, 1998·Journal of Pineal Research·D X TanG H El-Sokkary
May 18, 1999·Experimental Eye Research·R KannanN Kaplowitz
Mar 10, 2001·Progress in Neurobiology·M Ugarte, N N Osborne
Jul 23, 1999·Survey of Ophthalmology·N N OsborneM S Nash
Oct 14, 1998·Progress in Neurobiology·R J Reiter
Aug 31, 2010·Experimental Eye Research·Abeir BaltmrM Francesca Cordeiro

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