Retinal Oximetry and Vessel Diameter Measurements With a Commercially Available Scanning Laser Ophthalmoscope in Diabetic Retinopathy

Investigative Ophthalmology & Visual Science
Norman P BlairMahnaz Shahidi

Abstract

To test the hypothesis that retinal vascular diameter and hemoglobin oxygen saturation alterations, according to stages of diabetic retinopathy (DR), are discernible with a commercially available scanning laser ophthalmoscope (SLO). One hundred eighty-one subjects with no diabetes (No DM), diabetes with no DR (No DR), nonproliferative DR (NPDR), or proliferative DR (PDR, all had photocoagulation) underwent imaging with an SLO with dual lasers (532 nm and 633 nm). Customized image analysis software determined the diameters of retinal arteries and veins (DA and DV) and central retinal artery and vein equivalents (CRAE and CRVE). Oxygen saturations of hemoglobin in arteries and veins (SO2A and SO2V) were estimated from optical densities of vessels on images at the two wavelengths. Statistical models were generated by adjusting for effects of sex, race, age, eye, and fundus pigmentation. DA, CRAE, and CRVE were reduced in PDR compared to No DM (P ≤ 0.03). DV and CRVE were similar between No DM and No DR, but they were higher in NPDR than No DR (P ≤ 0.01). Effect of stage of disease on SO2A differed by race, being increased relative to No DM in NPDR and PDR in Hispanic participants only (P ≤ 0.02). Relative to No DM, SO2V was increa...Continue Reading

Citations

Apr 25, 2019·Acta Ophthalmologica·Ahmad A ArefMahnaz Shahidi
Sep 17, 2019·Annual Review of Vision Science·Jennifer J HunterJesse B Schallek
Oct 28, 2019·Acta Ophthalmologica·Maria Della Volpe WaizelMargarita G Todorova
Dec 14, 2019·International Journal of Retina and Vitreous·Maziyar M KhansariMahnaz Shahidi
Oct 16, 2018·Journal of Ophthalmology·Per KappelgaardMichael Larsen
May 19, 2021·Translational Vision Science & Technology·Anupam K GargDaniel L Chao
Jun 11, 2021·Translational Vision Science & Technology·Selin L AuvazianMahnaz Shahidi
Sep 22, 2021·Investigative Ophthalmology & Visual Science·Min-Woo LeeJung-Yeul Kim

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