PMID: 6165950Dec 1, 1980Paper

Retinal pigment epithelial abnormalities in fundus flavimaculatus: a light and electron microscopic study

Ophthalmology
R C EagleM Yanoff

Abstract

Light, fluorescent, and scanning and transmission electron microscopic examinations of two postmortem eyes from a 24-year-old man with well-documented fundus flavimaculatus with atrophic macular degeneration revealed striking abnormalities in the retinal pigment epithelium (RPE). Beginning near the equator, scanning electron microscopy demonstrated a progressively marked heterogeneity in the size of the RPE cells. Surrounded by a fairly regular mosaic of relatively normal appearing cells, enormously enlarged hypomelanotic cells measuring up to 80 microns in diameter occurred in irregular aggregates that became more prevalent posteriorly. Diffusely and intensely PAS-positive, the RPE was packed with a granular substance with ultrastructural, autofluorescent, and histochemical properties consistent with an abnormal form of lipofuscin. The greatest concentration of lipopigment was noted posteriorly. Stains for acid mucopolysaccharide were only mildly positive. The clinical and fluorescein angiographic manifestations of fundus flavimaculatus are consistent with accumulation of a lipofuscin-like substance in the RPE. The massive amounts of lipopigment encountered in this young individual suggest that disordered lipopigment metabolis...Continue Reading

References

Mar 1, 1977·Archives of Ophthalmology·R C HsiehJ S Lyons
Aug 1, 1976·Experimental Eye Research·G D Aguirre, A Laties

❮ Previous
Next ❯

Citations

Oct 12, 2011·Archives of Ophthalmology·Catherine A CukrasPaul A Sieving
Jan 1, 1995·International Ophthalmology·B A LafautJ J De Laey
Nov 1, 1985·International Ophthalmology·O Gelisken, J J De Laey
Aug 30, 1985·Documenta Ophthalmologica. Advances in Ophthalmology·G A Fishman
Aug 30, 1985·Documenta Ophthalmologica. Advances in Ophthalmology·K WakabayashiK Kawasaki
Jan 1, 1992·Documenta Ophthalmologica. Advances in Ophthalmology·M Mäntyjärvi, K Tuppurainen
Nov 1, 1992·International Ophthalmology·M Mäntyjärvi, K Tuppurainen
Oct 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·R ItabashiT Hirose
Jan 1, 1984·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M BoultonJ Mellerio
Sep 21, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Lena IvertPeter Gouras
Jun 7, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Frederick A JakobiecFouad R Zakka
Jan 1, 2012·Journal of Ocular Biology, Diseases, and Informatics·Sandeep SaxenaCarsten H Meyer
May 3, 2005·Experimental Eye Research·Janet R Sparrow, Mike Boulton
Dec 4, 2001·American Journal of Ophthalmology·I VooK W Small
Dec 28, 1999·American Journal of Ophthalmology·K ZhangR Allikmets
Dec 1, 1982·Ophthalmology·R C WatzkeR M Lang
Nov 1, 1987·Ophthalmology·A E UlissA C Bird
Jun 1, 1991·Ophthalmology·G A FishmanK R Alexander
Mar 21, 1998·Ophthalmology·J D ArmstrongJ L Elfervig
Aug 2, 2003·Progress in Retinal and Eye Research·Debra A Thompson, Andreas Gal
Sep 24, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Janet R SparrowJilin Zhou
Sep 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Gennadiy MoiseyevJian-xing Ma
Mar 11, 2008·Retina·Steffen Schmitz-ValckenbergRichard F Spaide
Jun 10, 2008·Retina·Maurizio Battaglia ParodiGiuseppe Ravalico
May 1, 1990·Australian and New Zealand Journal of Ophthalmology·G A Fishman
Aug 1, 1992·Australian and New Zealand Journal of Ophthalmology·P F Lopez, T M Aaberg
Dec 11, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Peter G SwannAphrodite Livanes
Jun 7, 2006·The British Journal of Ophthalmology·G QuerquesE H Souied
Sep 8, 2006·The British Journal of Ophthalmology·Vikki A McBainNoemi Lois
May 19, 2006·The British Journal of Ophthalmology·D M PaskowitzJ L Duncan
Oct 12, 2010·The British Journal of Ophthalmology·Mohamed A GeneadAnastasios Anastasakis
May 1, 1981·The British Journal of Ophthalmology·G FishA C Bird
Sep 1, 1993·The British Journal of Ophthalmology·R L SteinmetzA C Bird
Jun 1, 1994·The British Journal of Ophthalmology·W BacaA M Glenn
May 29, 1998·The British Journal of Ophthalmology·U KretschmannE Zrenner
Jun 30, 2000·The British Journal of Ophthalmology·N LoisF W Fitzke
Sep 10, 2003·Journal of Medical Genetics·M MichaelidesA T Moore
Jul 19, 2013·Investigative Ophthalmology & Visual Science·Jonathan P GreenbergFrançois C Delori
Jun 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·N L MataG H Travis
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Janet R Sparrow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.