Retinal pigment epithelium changes in pediatric patients with glaucoma drainage devices

American Journal of Ophthalmology Case Reports
Carla J OsigianAudina Berrocal

Abstract

Retinal changes secondary to hypotony are usually described as wrinkling or folding of the inner portion of the choroid, the retinal pigment epithelium (RPE), and the outer retinal layers in the macular area due to scleral wall collapse. We describe a new retinal finding in children with suspected hypotony after implantation of Baerveldt Glaucoma Implant (BGI). Four patients in our series developed significant RPE defects after BGI implant. The RPE defects appeared as elongated white lines observed solely in the posterior pole, in no particular pattern, and seemed to be worse in infants with anterior segment dysgenesis and with collagen disorders. Children have thinner and more elastic scleral walls than adults. This characteristic may cause the inward scleral wall to collapse when the eye is hypotonic. The resulting redundancy of the retina leads to wrinkling and RPE defects characterized by hypopigmented lines predominantly in the macular area. Such findings, to our knowledge, have not been previously reported in pediatric patients.

Citations

May 1, 2020·Scientific Reports·Francisco J Valiente-SorianoMarta Agudo-Barriuso
Apr 29, 2019·Survey of Ophthalmology·Qianqian WangDaniel Lee
Dec 11, 2021·Ophthalmic Genetics·Noy AshkenazyAudina M Berrocal

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