Retinal Pigment Epithelium Sequelae Caused by Blunt Ocular Trauma: Incidence, Visual Outcome, and Associated Factors

Scientific Reports
Seong Joon AhnByung Ro Lee

Abstract

Vision loss can occur in eyes with blunt ocular trauma, but the causes have not been elucidated fully. We encountered cases of retinal pigment epithelium (RPE) sequelae following blunt ocular trauma associated with permanent vision loss in our cohort of patients with blunt ocular trauma. In this multicentre retrospective cohort study on 129 patients with retinal abnormalities caused by acute blunt ocular trauma, we investigated the incidence of RPE sequelae and evaluated associated factors and visual outcomes. RPE sequelae, which typically presented as hyperpigmentation within well-demarcated hypopigmented lesions, occurred in 29 (22.5%) patients within 1 month of trauma. Optical coherence tomography (OCT) revealed complete photoreceptor loss over the abnormal RPE. Final visual outcomes were significantly different between eyes with and without RPE sequelae. Logistic regression analysis revealed a significant association between the presence of subretinal fluid and RPE sequelae. In conclusion, RPE sequelae occurred in approximately 20% of patients with blunt ocular trauma and was associated with permanent photoreceptor defects and visual loss. Clinical evaluation using OCT may help predict RPE sequelae and visual outcomes in ey...Continue Reading

References

Jul 1, 1979·American Journal of Ophthalmology·T R Friberg
Jul 14, 1998·Nature Genetics·K PetrukhinC Wadelius
Aug 25, 1999·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·A HayashiE de Juan
Nov 13, 2002·Archives of Ophthalmology·Joshua L DunaiefAnn H Milam
Aug 2, 2003·Progress in Retinal and Eye Research·Debra A Thompson, Andreas Gal
Apr 14, 2004·Archives of Ophthalmology·Marco A Zarbin
Feb 15, 2005·Progress in Retinal and Eye Research·Steven K FisherMark R Verardo
May 11, 2005·Archives of Ophthalmology·Gerald McGwin, Cynthia Owsley
Jul 13, 2005·Archives of Ophthalmology·Gerald McGwinCynthia Owsley
Sep 24, 2009·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Michael I SeiderCarmen A Puliafito
Oct 27, 2009·American Journal of Human Genetics·Alice E DavidsonForbes D C Manson
May 22, 2010·Experimental Eye Research·David J Strick, Douglas Vollrath
Feb 16, 2013·Survey of Ophthalmology·Benjamin NicholsonCatherine Meyerle
Apr 27, 2013·Ophthalmology·Richard J BlanchRobert A H Scott

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Citations

Nov 30, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Genjie KeYonghao Gu
Dec 22, 2020·Photodiagnosis and Photodynamic Therapy·Duygu Yalinbas YeterAli Hakan Durukan
Apr 10, 2021·International Medical Case Reports Journal·Yunia IrawatiMirta Hediyati Reksodiputro

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