Retinal prostheses: progress toward the next generation implants

Frontiers in Neuroscience
Diego Ghezzi

Abstract

In the last decade, various clinical trials proved the capability of visual prostheses, in particular retinal implants, to restore a useful form of vision. These encouraging results promoted the emerging of several strategies for neuronal stimulation aiming at the restoration of sight. Besides the traditional approach based on electrical stimulation through metal electrodes in the different areas of the visual path (e.g., the visual cortex, the lateral geniculate nucleus, the optic nerve, and the retina), novel concepts for neuronal stimulation have been mostly exploited as building blocks of the next generation of retinal implants. This review is focused on critically discussing recent major advancements in the field of retinal stimulation with particular attention to the findings in the application of novel concepts and materials. Last, the major challenges in the field and their clinical implications will be outlined.

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Citations

Mar 5, 2016·Frontiers in Neuroscience·Mufti Mahmud, Stefano Vassanelli
Feb 18, 2017·Scientific Reports·Alejandro Barriga-RiveraGregg J Suaning
Nov 18, 2017·Veterinary Ophthalmology·Alejandro Barriga-RiveraGregg J Suaning
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Mar 8, 2018·Nature Communications·Jing TangGengfeng Zheng
Mar 10, 2018·Nature Communications·Laura FerlautoDiego Ghezzi
Jun 28, 2019·Investigative Ophthalmology & Visual Science·Claudia LunghiMaria Concetta Morrone
Aug 21, 2019·Nature Biomedical Engineering·Vivien GailletDiego Ghezzi
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May 28, 2020·Micromachines·Shinyong ShimSung June Kim
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May 5, 2018·ACS Nano·John F Zimmerman, Bozhi Tian

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Methods Mentioned

BETA
pharmacotherapy
cochlear implants
chip

Software Mentioned

Silva

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