Retinal prosthetic strategy with the capacity to restore normal vision

Proceedings of the National Academy of Sciences of the United States of America
Sheila Nirenberg, Chethan Pandarinath


Retinal prosthetics offer hope for patients with retinal degenerative diseases. There are 20-25 million people worldwide who are blind or facing blindness due to these diseases, and they have few treatment options. Drug therapies are able to help a small fraction of the population, but for the vast majority, their best hope is through prosthetic devices [reviewed in Chader et al. (2009) Prog Brain Res 175:317-332]. Current prosthetics, however, are still very limited in the vision that they provide: for example, they allow for perception of spots of light and high-contrast edges, but not natural images. Efforts to improve prosthetic capabilities have focused largely on increasing the resolution of the device's stimulators (either electrodes or optogenetic transducers). Here, we show that a second factor is also critical: driving the stimulators with the retina's neural code. Using the mouse as a model system, we generated a prosthetic system that incorporates the code. This dramatically increased the system's capabilities--well beyond what can be achieved just by increasing resolution. Furthermore, the results show, using 9,800 optogenetically stimulated ganglion cell responses, that the combined effect of using the code and hi...Continue Reading


Aug 1, 1987·The Journal of Comparative Neurology·J F Dann, E H Buhl
Mar 1, 2003·BMJ : British Medical Journal·Amresh ChopdarDinesh Verma
Nov 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Georg NagelErnst Bamberg
Apr 14, 2004·Archives of Ophthalmology·Nathan CongdonUNKNOWN Eye Diseases Prevalence Research Group
Jun 25, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christian GrimmCharlotte Remé
Aug 25, 2004·Investigative Ophthalmology & Visual Science·Abigail S HackamDonald J Zack
May 7, 2005·Journal of Neural Engineering·Rolf EckmillerOliver Baruth
Jun 30, 2005·Journal of Neurophysiology·Robert E KassEmery N Brown
Aug 24, 2005·Nature Neuroscience·Edward S BoydenKarl Deisseroth
Feb 28, 2007·Journal of Neural Engineering·J D LoudinD V Palanker
Aug 21, 2007·Journal of Biomaterials Science. Polymer Edition·Jessica O WinterJoseph F Rizzo
Oct 11, 2007·Progress in Brain Research·Liam PaninskiJeremy Lewi
Apr 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chris SekirnjakE J Chichilnisky
Apr 29, 2008·The New England Journal of Medicine·Albert M MaguireJean Bennett
Feb 21, 2009·Nature Reviews. Neuroscience·Rodrigo Quian Quiroga, Stefano Panzeri
Mar 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Adam L JacobsSheila Nirenberg
Aug 8, 2009·Progress in Brain Research·Gerald J ChaderMark S Humayun
Aug 14, 2009·The New England Journal of Medicine·Artur V CideciyanSamuel G Jacobson
Sep 18, 2009·Nature·Katherine MancusoMaureen Neitz
Dec 3, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Francesca SimonelliAlberto Auricchio
Jul 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Senthil ThyagarajanHeinz Wässle
Mar 29, 2011·Nature Neuroscience·Heidi A BaselerAntony B Morland
Apr 21, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·M Mehdi DoroudchiAlan Horsager

❮ Previous
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Feb 28, 2013·Nature Communications·Inna Reutsky-GefenShy Shoham
Jun 4, 2013·Annual Review of Neuroscience·José-Alain Sahel, Botond Roska
Jan 24, 2013·PloS One·Illya BomashSheila Nirenberg
Sep 13, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zachary NicholsJonathan Victor
Aug 8, 2014·Visual Neuroscience·John Martin BarrettPatrick Degenaar
Feb 15, 2014·British Medical Bulletin·Yvonne H-L Luo, Lyndon da Cruz
Mar 1, 2016·Frontiers in Cellular Neuroscience·Vidhyasankar KrishnamoorthyNarender K Dhingra
Feb 24, 2016·Frontiers in Neuroscience·Salvador Dura-BernalWilliam W Lytton
Dec 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Benjamin M GaubEhud Y Isacoff
Apr 2, 2013·Neuroscience Research·Seiji Tanabe
Sep 26, 2015·Progress in Retinal and Eye Research·Yvonne Hsu-Lin Luo, Lyndon da Cruz
Jun 21, 2015·Neuropsychologia·Hannes P Saal, Sliman J Bensmaia
Sep 18, 2015·Frontiers in Cellular Neuroscience·John M BarrettEvelyne Sernagor
Nov 13, 2012·Current Opinion in Pharmacology·Marco Attilio ZarbinRobert Ritch
Aug 5, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ione Fine, Geoffrey M Boynton
May 15, 2013·Neuron·David H GireLaura Lopez-Mascaraque
Nov 15, 2012·Journal of Physiology, Paris·Henri LorachSerge Picaud
Dec 25, 2012·Journal of Physiology, Paris·Tim Gollisch
Feb 6, 2015·Translational Vision Science & Technology
Jul 23, 2013·Behavioural Brain Research·Jan Tønnesen
Dec 9, 2014·Nature Neuroscience·Alexandra Tikidji-HamburyanThomas A Münch
Nov 15, 2014·ELife·Ann M HermundstadGašper Tkačik
May 31, 2016·Progress in Retinal and Eye Research·Lan YueMark S Humayun
Aug 2, 2016·Neuron·Johnatan AljadeffDavid Kleinfeld
Jul 22, 2016·Human Gene Therapy·Shannon E BoyePaul D Gamlin
Aug 12, 2016·Experimental Neurology·Daniel J O'SheaKrishna V Shenoy
Aug 24, 2016·ELife·Sébastien RouxFrédéric Chavane
Dec 21, 2016·PLoS Computational Biology·Laurence AitchisonPeter E Latham
Jan 10, 2018·Frontiers in Neuroscience·Jean DelbekeDimiter Prodanov
Apr 25, 2017·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Amr JawwadSeif Eldawlatly
Aug 30, 2018·Journal of Neural Engineering·Ahmed SoltanPatrick Degenaar
May 7, 2016·Science Advances·Tomoyuki YokotaTakao Someya
Dec 14, 2018·Journal of Neural Engineering·James R GoldenE J Chichilnisky
Dec 4, 2015·Journal of Neurophysiology·Arani RoyStephen D Van Hooser
May 26, 2016·Journal of Neural Engineering·David PerruchoudSilvio Ionta

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