Retinal Protection and Distribution of Curcumin in Vitro and in Vivo

Frontiers in Pharmacology
Chiara Bianca Maria PlataniaClaudio Bucolo

Abstract

Diabetic retinopathy (DR), a secondary complication of diabetes, is a leading cause of irreversible blindness accounting for 5% of world blindness cases in working age. Oxidative stress and inflammation are considered causes of DR. Curcumin, a product with anti-oxidant and anti-inflammatory properties, is currently proposed as oral supplementation therapy for retinal degenerative diseases, including DR. In this study we predicted the pharmacodynamic profile of curcumin through an in silico approach. Furthermore, we tested the anti-oxidant and anti-inflammatory activity of curcumin on human retinal pigmented epithelial cells exposed to oxidative stress, human retinal endothelial and human retinal pericytes (HRPCs) cultured with high glucose. Because currently marketed curcumin nutraceutical products have not been so far evaluated for their ocular bioavailability; we assessed retinal distribution of curcumin, following oral administration, in rabbit eye. Curcumin (10 μM) decreased significantly (p < 0.01) ROS concentration and TNF-α release in retinal pigmented epithelial cells and retinal endothelial cells, respectively. The same curcumin concentration significantly (p < 0.01) protected retinal pericytes from high glucose damage...Continue Reading

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Citations

Apr 17, 2019·Nutrients·Maria Grazia Rossino, Giovanni Casini
Mar 4, 2020·International Journal of Molecular Sciences·Claudia G FrestaClaudio Bucolo
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Methods Mentioned

BETA
nuclear translocation
Assay
ELISA
sedation

Clinical Trials Mentioned

NCT02984813
NCT01646047

Software Mentioned

GraphPad Prism
SwissTargetPrediction
Schrödinger© maestro
GraphPad
Prime

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