Retinal sensitivity in subjects with type 2 diabetes mellitus: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SN-DREAMS II, Report No. 4)

The British Journal of Ophthalmology
Laxmi GellaTarun Sharma

Abstract

To evaluate retinal sensitivity (RS) in subjects with diabetes in a population-based study and to elucidate associated risk factors for abnormal RS. A subset of 357 subjects from Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study-II was included in this study. All subjects underwent detailed ophthalmic evaluation including microperimetry and spectral domain optical coherence tomography. The prevalence of abnormal mean retinal sensitivity (MRS) was 89.1%. MRS was significantly reduced in subjects with diabetes but no retinopathy when compared with non-diabetic subjects. MRS was reduced in moderate non-proliferative diabetic retinopathy (DR) and macular oedema (ME) at 8° (p=0.04, p=0.01, respectively) and in ME at 10° (p=0.009) and 12° (p=0.036) compared with no DR. Significant negative correlation was found between MRS and best corrected visual acuity, duration of diabetes, glycosylated haemoglobin and central foveal thickness. Increased retinal thickness remained a significant risk factor (OR, 1.02; p=0.044) for abnormal MRS. Altered inner retinal layers and foveal contour were associated with reduced MRS among subjects with DR and presence of epiretinal membrane, altered foveal contour and altere...Continue Reading

References

Sep 1, 1986·Ophthalmology·R KleinM D Davis
Jan 1, 1985·Archives of Ophthalmology·S SokolB Senior
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Mar 27, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alistair J Barber
Apr 14, 2004·Archives of Ophthalmology·John H KempenUNKNOWN Eye Diseases Prevalence Research Group
Apr 11, 2006·Japanese Journal of Ophthalmology·Miki SawaYasuo Tano
Jun 27, 2006·Investigative Ophthalmology & Visual Science·Stela VujosevicFabiano Cavarzeran
Aug 28, 2009·Investigative Ophthalmology & Visual Science·Chi D LuuTien Y Wong
May 21, 2010·Investigative Ophthalmology & Visual Science·Gábor György DeákUNKNOWN Diabetic Retinopathy Research Group Vienna
Jun 24, 2011·American Journal of Ophthalmology·Elham HatefDiana V Do
Dec 15, 2011·Journal of Ophthalmic Inflammation and Infection·Yasir J SepahQuan Dong Nguyen
Mar 28, 2012·Retina·Muneeswar G NittalaTarun Sharma
Apr 27, 2013·Indian Journal of Ophthalmology·Laxmi GellaRajiv Raman
May 26, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ragnhild Wivestad JanssonJørgen Krohn

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Citations

Jan 22, 2017·The British Journal of Ophthalmology·Srividya NeriyanuriRajiv Raman
Dec 3, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mario R RomanoGiovanni Cennamo
Oct 5, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·E SongChen-Wei Pan
Dec 19, 2019·Current Eye Research·Jason C ParkJ Jason McAnany
Jun 14, 2018·Experimental and Therapeutic Medicine·Xuegu XuYinfei Yu
May 13, 2019·American Journal of Ophthalmology·Richard F Spaide
Feb 11, 2021·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Yesa Yang, Hannah Dunbar

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