Retinal tissue hypoperfusion in patients with clinical Alzheimer's disease

Eye and Vision
Giovana Rosa GameiroJianhua Wang

Abstract

It remains unknow whether retinal tissue perfusion occurs in patients with Alzheimer's disease. The goal was to determine retinal tissue perfusion in patients with clinical Alzheimer's disease (CAD). Twenty-four CAD patients and 19 cognitively normal (CN) age-matched controls were recruited. A retinal function imager (RFI, Optical Imaging Ltd., Rehovot, Israel) was used to measure the retinal blood flow supplying the macular area of a diameter of 2.5 mm centered on the fovea. Blood flow volumes of arterioles (entering the macular region) and venules (exiting the macular region) of the supplied area were calculated. Macular blood flow was calculated as the average of arteriolar and venular flow volumes. Custom ultra-high-resolution optical coherence tomography (UHR-OCT) was used to calculate macular tissue volume. Automated segmentation software (Orion, Voxeleron LLC, Pleasanton, CA) was used to segment six intra-retinal layers in the 2.5 mm (diameter) area centered on the fovea. The inner retina (containing vessel network), including retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), inner nuclear layer (INL) and outer plexiform layer (OPL), was segmented and tissue volume was calculated. Perfusion w...Continue Reading

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Citations

May 3, 2019·Current Eye Research·Yi LiuJianhua Wang
Feb 21, 2019·Investigative Ophthalmology & Visual Science·Ying LinJianhua Wang
Dec 4, 2019·Current Opinion in Neurology·Oana M Dumitrascu, Maya Koronyo-Hamaoui
Dec 7, 2019·Current Opinion in Neurology·Gregory P Van Stavern
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Dec 29, 2019·Scientific Reports·Breanna M TraceyOsamah J Saeedi
Nov 3, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Hong JiangTania Rundek

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