PMID: 3756121Sep 1, 1986Paper

Retinal toxicity of amphotericin B in vitrectomised versus non-vitrectomised eyes

The British Journal of Ophthalmology
J BaldingerB Johnson

Abstract

The retinal toxicity of intravitreally administered amphotericin B was compared in non-vitrectomised versus vitrectomised rabbit eyes. Doses of 5 and 10 micrograms in both groups resulted in transient vitritis but had no effect on electroretinograms. Histopathological examination four weeks after injection showed vitreous cells and minimal areas of retinal necrosis in both groups at 5 or 10 micrograms doses. At these doses vitrectomy did not modify the retinotoxic effects of intravitreally administered amphotericin B. At higher doses marked toxicity was found in both vitrectomised and non-vitrectomised groups.

References

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Citations

Oct 27, 2005·Documenta Ophthalmologica. Advances in Ophthalmology·Joseph M HarrisonRobert Melendez
Nov 1, 1985·Ophthalmology·B H DoftL B Wingard
Apr 1, 1995·American Journal of Ophthalmology·J K LuttrullH A Oster
Nov 15, 1993·American Journal of Ophthalmology·M VelikayS Binder
Oct 22, 2002·Journal of Cataract and Refractive Surgery·Klaus D Teichmann
May 20, 2008·Ophthalmology·Charles C WykoffEduardo C Alfonso
Oct 30, 2016·Seminars in Ophthalmology·Yewlin E Chee, Dean Eliott
Sep 24, 2014·Antimicrobial Agents and Chemotherapy·Ying-Cheng ShenLi-Chen Wei
Nov 27, 2018·European Journal of Ophthalmology·Hande Celiker, Haluk Kazokoglu
Nov 28, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Prit LakhaniSoumyajit Majumdar
Oct 3, 2006·Expert Review of Anti-infective Therapy·Ahmed SallamSue Lightman
Jan 13, 2018·Therapeutic Delivery·Prit LakhaniSoumyajit Majumdar
Apr 11, 2020·Ocular Immunology and Inflammation·Sagnik SenKim Ramasamy
Apr 25, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Akash Patil, Soumyajit Majumdar

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