Retinal transplantation using surface modified poly(glycerol-co-sebacic acid) membranes.

Biomaterials
Christopher D PritchardFredrik Ghosh

Abstract

In retinal transplantation experiments it is hypothesized that remaining diseased photoreceptor cells in the host retina and inner retinal cells in transplants physically obstruct the development of graft-host neuronal contacts which are required for vision. Recently, we developed methods for the isolation of donor photoreceptor layers in vitro, and the selective removal of host photoreceptors in vivo using biodegradable elastomeric membranes composed of poly(glycerol-co-sebacic acid) (PGS). We also coated PGS membranes with electrospun nanofibers, composed of laminin and poly(epsilon-caprolactone) (PCL), to promote attachment of embryonic retinal explants, allowing the resulting composites to be handled surgically as a single entity. Here, we report subretinal transplantation of these composites into adult porcine eyes. In hematoxylin and eosin stained sections of composite explants after 5-7 days in vitro, excellent fusion of retinas and biomaterial membranes was noted, with the immature retinal components showing laminated as well as folded and rosetted areas. The composite grafts could be transplanted in all cases and, 3 months after surgery, eyes displayed clear media, attached retinas and the grafts located subretinally. ...Continue Reading

References

Jan 1, 1992·Experimental Neurology·S T Schuschereba, M S Silverman
Feb 13, 1999·Experimental Eye Research·F GhoshB Ehinger
Jun 4, 2002·Nature Biotechnology·Yadong WangRobert Langer
Apr 18, 2007·Cell Transplantation·Karl Engelsberg, Fredrik Ghosh
Oct 27, 2007·Biomaterials·William L NeeleyRobert Langer
Feb 26, 2008·Biomaterials·Christopher J BettingerRobert S Langer
Oct 1, 2008·Biomaterials·Joost P BruggemanRobert Langer
Oct 11, 2008·Tissue Engineering. Part C, Methods·Rebekah A NealEdward A Botchwey
Oct 22, 2008·Investigative Ophthalmology & Visual Science·Fredrik GhoshKarl Engelsberg
Dec 8, 2009·Biomaterials·Christopher D PritchardFredrik K Ghosh
Feb 13, 2010·Developmental Neuroscience·Fredrik Ghosh, Karin Arnér

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Citations

Oct 17, 2013·Journal of the American Chemical Society·Mausam KalitaBalagurunathan Kuberan
Nov 14, 2012·Developmental Neuroscience·Fredrik GhoshKarin Arnér
Mar 25, 2016·ACS Applied Materials & Interfaces·Shaofei WangYadong Wang
Mar 13, 2014·Experimental Eye Research·Kristan S WorthingtonBudd A Tucker
Dec 17, 2014·Biomacromolecules·Jinyoung YangJihoon Shin
Mar 19, 2015·Experimental Eye Research·Lisanne M NibourgSteven A Koopmans
Feb 19, 2015·Frontiers in Bioengineering and Biotechnology·Tamer A E AhmedMay Griffith
Dec 10, 2016·Journal of Biomedical Materials Research. Part a·Loran D SolorioScott J Hollister
May 4, 2018·Chemical Society Reviews·Hongye YeXian Jun Loh
Aug 16, 2018·Advanced Materials·Yei Hwan JungZhenqiang Ma
Jan 14, 2020·Journal of Biomaterials Applications·Samand Pashneh-TalaFrederik Claeyssens
Jul 26, 2011·Journal of Biomaterials Science. Polymer Edition·Sophie CaiMichael Joseph Young
Oct 4, 2020·Experimental Eye Research·Chang-Jun ZhangZi-Bing Jin
Nov 2, 2021·Translational Vision Science & Technology·Allison L Ludwig, David M Gamm

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