Retinal Vascular Branching in Healthy and Diabetic Subjects

Investigative Ophthalmology & Visual Science
Ting LuoStephen A Burns

Abstract

To measure the effect of nonproliferative diabetic retinopathy (NPDR) on retinal branching. To compare vascular branching in healthy and diabetic subjects with established biophysical models. Vascular bifurcations in arteries and veins were imaged in 17 NPDR and 26 healthy subjects with the Indiana adaptive optics scanning laser ophthalmoscope (AOSLO). Vessel measurements were grouped according to parent vessel diameters into large (≤50 ∼ <100 μm) and small (≤20 ∼ <50 μm) sizes. Vessel diameters and bifurcation angles were measured manually. Vascular diameters were compared with predictions of Murray's law using curve fitting. For analysis of bifurcation angles, two models from Zamir were compared: one based on the power required for blood pumping, the other based on drag force between blood and vascular wall. For normal larger vessels, the exponent relating the parent and daughter branching diameters was significantly less than the value of 3 predicted by Murray's law (arteries: 2.59; veins: 1.95). In NPDR, the best-fit exponent was close to 3 for arteries but close to 2 in healthy subjects in veins, (arteries: 3.09; veins: 2.16). For both small arteries and veins, diabetics' exponent differed from healthy subjects (P < 0.01)....Continue Reading

Citations

Oct 17, 2019·PloS One·William H SwansonStephen A Burns
Aug 29, 2020·Journal of Biophotonics·Wei WeiRuikang K Wang
Dec 5, 2019·Biomedical Optics Express·Phillip Bedggood, Andrew Metha
Dec 5, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Phillip Bedggood, Andrew Metha
Oct 1, 2020·Scientific Reports·Raymond L WarnerStephen A Burns
Mar 16, 2018·Biomedical Optics Express·Kaitlyn A SapoznikStephen A Burns
Dec 2, 2020·Eye·Engin AkyolAndrew J Lotery
Jun 7, 2021·Survey of Ophthalmology·Elise BakkerMichel Paques
Jun 26, 2021·Annual Review of Vision Science·Stephen A BurnsThomas J Gast

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