Retinal vessel analysis in hypercholesterolemic patients before and after LDL apheresis

Atherosclerosis. Supplements
Manja ReimannTjalf Ziemssen

Abstract

Changes in the microcirculation per se may precede macrovascular changes, hence, may present a good surrogate for monitoring vascular changes during treatment. Using retinal vascular imaging techniques, we attempted to investigate the microvascular benefit of a single LDL apheresis in hypercholesterolemia. Twenty-one hypercholesterolemic patients (57+/-15 years) on regular LDL apheresis treatment, seven women and 14 men, were examined for retinal endothelial function before and after a single LDL apheresis. The Dynamic Vessel Analyzer was applied for static and dynamic retinal vessel analysis. Retinal vessel diameter was measured at rest and during flicker light stimulation. Changes in vasodilation are expressed as percent changes over baseline. Cholesterol fractions and triglycerides were reduced by 21-74 % by the LDL apheresis procedure. In hypercholesterolemic patients, flicker-induced vasodilation was diminished in both retinal arterioles and venules, but had significantly improved in retinal venules after a single LDL apheresis (p = 0.013). This increase in vasodilatory capacity of retinal venules was linked to a wider basal retinal venular caliber (p = 0.031), but was unrelated to changes in serum lipids (p > 0.05). In hy...Continue Reading

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Citations

Feb 13, 2013·European Heart Journal·Josef FlammerStefano Taddei
Apr 27, 2012·Thrombosis and Haemostasis·Rebekka Heitmar, Robert James Summers
Jul 8, 2015·Acta Ophthalmologica·Swathi SeshadriDoina Gherghel
Aug 17, 2010·Atherosclerosis·Manja ReimannTjalf Ziemssen
Nov 16, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Michelle LimCarol Y Cheung
Mar 24, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·C T McEvoyM C McKinley
May 6, 2015·Atherosclerosis. Supplements·Manja ReimannTjalf Ziemssen
Jan 17, 2015·The American Journal of Cardiology·Ali H Al-FiadhOmar Farouque
Oct 21, 2016·Archives of Gynecology and Obstetrics·Alessandro RabioloFrancesco Bandello
Feb 9, 2017·Pharmacology & Therapeutics·Christine T O NguyenMagnus Ivarsson
May 22, 2019·International Angiology : a Journal of the International Union of Angiology·Anna MachalińskaBogusław Machaliński
Jul 5, 2019·European Journal of Heart Failure·Jens BarthelmesAndreas J Flammer
Aug 4, 2018·Retina·Alessandro RabioloGiuseppe Querques
May 12, 2018·Journal of Cardiovascular Development and Disease·Ulrich Julius
Jul 30, 2014·The Open Ophthalmology Journal·Stephan KremmerMichael Selbach J
Nov 30, 2019·Oxidative Medicine and Cellular Longevity·Jenia Kouchek ZadehAdrian Gericke
Sep 27, 2020·Clinical Physiology and Functional Imaging·Holger SchirutschkeJens Passauer

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