Retinal vessel diameter obtained by optical coherence tomography is spared in Parkinson's disease

International Ophthalmology
Duygu Gulmez SevimAyse Ozturk Oner

Abstract

To define the alterations in retinal vessel diameter in Parkinson's disease (PD) by optical coherence tomography (OCT). This is a case-control study including 41 eyes of 41 patients with diagnosis of PD and 35 eyes of 35 age- and sex-matched control subjects. All subjects underwent complete neurological and ophthalmological examinations before measurements. Retinal vessel diameters and peripapillary retinal nerve fiber layer (pRNFL) thicknesses were evaluated with spectral domain OCT (SD-OCT) with a circular scan centered at the optic disc. The diameters of the superior nasal and temporal arteries and veins, and inferior nasal and temporal arteries and veins were measured and then compared between the groups. Correlations with the duration of the disease, usage of levodopa, and pRNFL thicknesses between retinal vessel diameters were examined with Pearson and Spearman correlation analysis. Average pRNFL thickness is significantly decreased in PD compared to age- and sex-matched controls (p < 0.05). At all measurement points, retinal artery diameter measurements were decreased in the PD group compared to controls, but the differences did not reach statistical significance. Diameters of the retinal veins also did not show any sign...Continue Reading

References

Sep 3, 2004·Vision Research·Rivka InzelbergAvinoam Ophir
May 23, 2006·Lancet Neurology·Lonneke M L de Lau, Monique M B Breteler
Oct 13, 2007·European Journal of Ophthalmology·G F YavasF Oztürk
Oct 27, 2007·Documenta Ophthalmologica. Advances in Ophthalmology·Ozgül AltintaşYusuf Cağlar
Sep 3, 2009·Nature Reviews. Neurology·Wandana Nanhoe-MahabierBastiaan R Bloem
Oct 29, 2011·NeuroImage·María A Fernández-SearaMaría A Pastor
Nov 4, 2011·Nature Reviews. Neuroscience·Berislav V Zlokovic
Apr 20, 2012·PloS One·Philipp AlbrechtAxel Methner
Aug 18, 2012·Brain Pathology·Jian GuanLouise F B Nicholson
Aug 18, 2012·Journal of Ophthalmology·Eric M ShrierIvan Bodis-Wollner
Sep 28, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Raymond S SchwartzJillian J Kril
Dec 25, 2012·Journal of Neural Transmission·B SpundI Bodis-Wollner
Aug 3, 2013·Journal of Neural Transmission·Max SchneiderElmar H Pinkhardt
Mar 1, 2014·Investigative Ophthalmology & Visual Science·Kyoko KumagaiNagahisa Yoshimura
Aug 13, 2014·Acta Ophthalmologica·Alexander Karl-Georg SchusterUrs Vossmerbaeumer
Sep 8, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Thekkuttuparambil Ananthanarayanan Ajith, Ranimenon
Oct 9, 2015·Neurology·Helena M van der HolstFrank-Erik de Leeuw
Oct 21, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Deanna P LyttleRichard W Madsen
Jul 12, 2016·Parkinsonism & Related Disorders·Heidi FooNagaendran Kandiah
Oct 18, 2016·Investigative Ophthalmology & Visual Science·Anastasia PilatIrene Gottlob

❮ Previous
Next ❯

Citations

Oct 28, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Wen-Chuan ZhouJing Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.