Retinal vessel metrics: normative data and their use in systemic hypertension: results from the Gutenberg Health Study

Journal of Hypertension
Katharina A PontoAlireza Mirshahi

Abstract

In-vivo measurement of retinal vascular calibers may be used as a tool to study the pathophysiology and clinical status of the microvasculature of the retina. The aim of this study was to generate normative data for retinal vessel parameters, and to evaluate the clinical relevance in systemic hypertension. Fundus photographs from 4309 participants of the Gutenberg Health Study were assessed using the 'retinal vessel analyzer' software (IMEDOS). We generated age and sex-specific nomograms in a disease-free subpopulation of 890 participants for determining the central retinal arteriolar equivalent (CRAE), the central retinal venular equivalent, and the arteriovenous ratio (AVR). Women had higher values of CRAE, central retinal venular equivalent, and AVR than men, and the decrease in measures with increasing age was less steep in women than in men. Systemic hypertension was associated with lower values [odds ratio (OR), 95% confidence interval (CI) referring to area below the 5% percentile] of AVR (men: OR 2.41, 95% CI 1.669-3.490, P < 0.001; women: OR 3.01, 95% CI 2.126-4.268, P < 0.001) and CRAE (men: OR 2.60, 95% CI 1.563-4.326, P < 0.001, women: OR 3.00, 95% CI 2.004-4.487, P < 0.001). Both median CRAE and AVR were lower in p...Continue Reading

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Citations

Jun 29, 2017·Journal of Hypertension·Alfons J H M HoubenGuido Grassi
Feb 1, 2018·Journal of Clinical Periodontology·Stefanie SamietzFrank Tost
Apr 9, 2020·Annals of Intensive Care·Jurate SimkieneAndrius Pranskunas
Dec 15, 2020·European Journal of Ophthalmology·Manuel Ap VilelaMaria Angélica T Ferreira

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