Retinal vessel regulation at high altitudes1

Clinical Hemorheology and Microcirculation
Thomas NeumannChristian Jung

Abstract

To measure static and dynamic changes of retinal vessels in response to normobaric hypoxia (NH, study A) and hypobaric hypoxia (HH, study B). Study A included 10 healthy individuals exposed to a simulated altitude of 5500 meters in a NH chamber; study B included 17 individuals studied after ascent to 3000-meter altitude. Retinal vessel diameter, response to flicker light, retinal oxygen saturation and retinal venous pressure were measured at baseline, under the corresponding hypoxia condition. The effects of macitentan, an endothelin receptor antagonist, were examined in study B. The mean age of participants was 34.6±9.3 years in study A and 36.7±10.8 years in study B. Retinal arterial and venous diameter increased, arterial and venous response to flicker light decreased, while retinal oxygen saturation remained stable under both experimental conditions. Retinal venous pressure increased in six individuals after ascent to 3000 meters and normalized after macitentan treatment. The occurrence of acute mountain sickness (AMS) correlated only with the decrease of arterial constriction after ascent to 3000 meters. Retinal arterial and venous vessels react to NH and HH with a diameter increase and an impaired response to flicker ligh...Continue Reading

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Citations

Dec 7, 2017·The EPMA Journal·Katarzyna Konieczka, Carl Erb
May 29, 2019·Current Opinion in Critical Care·Christian Jung
Jul 25, 2019·Frontiers in Physiology·Lukas StreeseHenner Hanssen
Aug 29, 2016·Clinical Hemorheology and Microcirculation·Christian JungMalte Kelm

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