Retino-retinal projection in juvenile and young adult rats and mice

Experimental Eye Research
Francisco M Nadal-NicolásMarta Agudo-Barriuso

Abstract

Identification of retino-retinal projecting RGCs (ret-ret RGCs) has been accomplished by tracing RGCs in one retina after intravitreal injection of different tracers in the other eye. In mammals, rabbit and rat, ret-ret RGCs are scarce and more abundant in newborn than in adult animals. To our knowledge, ret-ret RGCs have not been studied in mice. Here we purpose to revisit the presence of ret-ret RGCs in juvenile and young adult rats and mice by using retrograde tracers applied to the contralateral optic nerve instead of intravitreally. In P20 (juvenile) and P60 (young adult) animals, the left optic nerve was intraorbitally transected and Fluorogold (rats) or its analogue OHSt (mice) were applied onto its distal stump. P20 animals were sacrificed 3 (mice) or 5 (rats) days later and adult animals at 5 (mice) or 7 (rats) days. Right retinas were dissected as flat-mounts and double immunodetected for Brn3a and melanopsin. Ret-ret RGCs were those with tracer accumulation in their somas. Out of them some expressed Brn3a and/or melanopsin, while other were negative for both markers. In young adult rats, we found 2 ret-ret RGCs displaced to the inner nuclear layer. In both species, ret-ret RGCs are quite scarce and found predominantl...Continue Reading

References

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Citations

Feb 22, 2016·Journal of Neuroinflammation·Anaïs SapienzaStéphane Melik Parsadaniantz
Dec 9, 2016·Scientific Reports·Francisco M Nadal-NicolásMarta Agudo-Barriuso
Nov 11, 2017·Journal of Neuroinflammation·Francisco M Nadal-NicolásMarta Agudo-Barriuso
Aug 4, 2019·Molecular Neurobiology·María Florencia González FleitasRuth E Rosenstein
Nov 17, 2019·International Journal of Molecular Sciences·Fernando Lucas-RuizMarta Agudo-Barriuso
Oct 21, 2019·Journal of Neurochemistry·Sergi Roig-PuiggrosAlain Chédotal
Dec 30, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·Gonzalo OrtizRadouil T Tzekov
Mar 18, 2016·Journal of Neurophysiology·Xiaolan TangChristopher L Passaglia
Jul 7, 2019·International Journal of Molecular Sciences·Verónica Murcia-Belmonte, Lynda Erskine
Dec 9, 2020·Development·Shane D'Souza, Richard A Lang
Dec 11, 2020·International Journal of Molecular Sciences·Xandra PereiroElena Vecino

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