Retinoblastoma - MR appearance using a surface coil in comparison with histopathological results.

European Radiology
Arne-Jörn LemkeN Hosten

Abstract

The purpose of this work was to evaluate the characteristic appearance of untreated retinoblastoma on a large sample in comparison to the histological findings after therapeutical enucleation. In a prospective clinical trial 46 children with retinoblastoma in 63 affected untreated eyes were examined under general anesthesia on MRI using a 1.5-T system. The examinations were performed with a special surface coil applying an examination protocol including fast T2- and T1-weighted spin echo sequences and additional fast T1-WI after intravenous injection of Gd-DTPA in different planes. The imaging results were compared to the histopathological findings in 29 patients with 30 affected eyes. Comparing MRI findings and histopathological results, optic nerve infiltration was detected with a sensitivity of 53.8% and a specificity of 82.3% on MRI, infiltration of the choroid with a sensitivity of 75.0% and a specificity of 100.0%, and the degree of tumor calcification with a sensitivity of 91.7% and a specificity of 88.9%. In this study the characteristic MR appearance of untreated retinoblastoma was evaluated. MRI was helpful in relevant aspects of pretherapeutical retinoblastoma staging, deficits remain regarding optic nerve infiltration.

References

Jan 1, 1979·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·J François, J Koliopoulos
Feb 1, 1991·Ophthalmology·E P MessmerW Sauerwein
Sep 1, 1988·Radiology·R G PeysterM E Haskin
Sep 1, 1986·Acta Radiologica: Diagnosis·S Lindahl
Aug 1, 1985·Ophthalmology·B G HaikD J Coleman
May 1, 1966·The British Journal of Ophthalmology·A Taktikos
Nov 1, 1984·Ophthalmology·D H CharD Norman
Jan 1, 1994·Neuroradiology·R G Beets-TanK E Tan
Sep 1, 1993·The British Journal of Ophthalmology·C L ShieldsP V De Potter
Jun 1, 1996·American Journal of Ophthalmology·P C Davis, N J Newman
Jan 1, 1997·European Radiology·F BarkhofJ Valk
Jan 1, 1997·Frontiers of Radiation Therapy and Oncology·N Hosten, A J Lemke
Apr 17, 1998·The Journal of Pediatrics·D H AbramsonN W Boyd
Jul 25, 1998·Klinische Monatsblätter für Augenheilkunde·A BalmerS Uffer
May 2, 2000·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A O Schüler, N Bornfeld
Feb 25, 2003·The British Journal of Ophthalmology·A O SchuelerN Bornfeld
Feb 8, 2005·Radiology·Pim de GraafJonas A Castelijns

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Citations

Aug 19, 2011·Pediatric Radiology·Pim de GraafUNKNOWN European Retinoblastoma Imaging Collaboration (ERIC)
Jul 11, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ellen M ChungJason W Schroeder
Sep 15, 2012·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Andreas M RauscheckerHeike E Daldrup-Link
Aug 19, 2011·The British Journal of Radiology·A A K A Razek, S Elkhamary
Jul 21, 2009·AJNR. American Journal of Neuroradiology·P GalluzziC Venturi
Oct 29, 2011·AJNR. American Journal of Neuroradiology·P de GraafJ A Castelijns
May 26, 2012·AJNR. American Journal of Neuroradiology·F RodjanP J W Pouwels
Oct 9, 2012·AJNR. American Journal of Neuroradiology·K TanitameK Awai
May 19, 2009·Pediatric Radiology·Hervé J Brisse
Feb 1, 2011·Seminars in Ultrasound, CT, and MR·Ajay MalhotraDelilah Burrowes
Feb 1, 2011·Seminars in Ultrasound, CT, and MR·Amit MahajanMiguel A Materin
May 5, 2010·Ophthalmology·Hervé J Brisse, UNKNOWN European Retinoblastoma Imaging Collaboration
Mar 5, 2014·Ophthalmology·Marcus C de JongUNKNOWN European Retinoblastoma Imaging Collaboration (ERIC)
Apr 22, 2015·Survey of Ophthalmology·Marcus C de JongUNKNOWN European Retinoblastoma Imaging Collaboration (ERIC)
Sep 29, 2012·European Journal of Radiology·Kyoung Doo SongTae Yeon Jeon
Dec 20, 2014·AJNR. American Journal of Neuroradiology·F RodjanUNKNOWN European Retinoblastoma Imaging Collaboration
Dec 2, 2017·Journal of Magnetic Resonance Imaging : JMRI·Marcus C de JongLouise van der Weerd
Oct 17, 2019·Journal of Magnetic Resonance Imaging : JMRI·Zhenzhen LiJunfang Xian
Jan 30, 2021·AJNR. American Journal of Neuroradiology·V M SilveraL A Dalvin

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