Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma

Molecular Medicine Reports
Marília Gerhardt de OliveiraRamon Andrade de Mello

Abstract

The retinoblastoma (Rb) and p53 genes play a fundamental role in cell cycle mechanisms, and their deregulation is related to many steps of oral cancer carcinogenesis. This study was conducted to evaluate the expression of the p53 and Rb proteins in malignant and pre-malignant oral cavity lesions. This retrospective study was conducted at the Federal University of Bahia, Salvador, Brazil, and the Molecular Biology Laboratory of the Otorhinolaryngology Department at the University of Heidelberg, Heidelberg, Germany. Excisional biopsy samples of oral cavities were collected from patients with suspected oral lesions. The samples were processed by immunohistochemistry to be classified by a semi-quantitative score: samples with a ≤ 10% positivity were considered to have weak/negative expression (-); those with 11-50% positivity, moderate expression (+); and those with >50% positivity, high expression (++). Seventy-one patients were studied (75% male; median age, 52 years; range, 24-84). Of the samples studied, 59.4% were oral squamous cell carcinoma (OSCC) and 40.6% were pre-neoplastic lesions (leukoplakia and actinic cheilitis). OSCC presented higher expression of Rb protein compared to pre-malignant lesions: 75 vs. 25% (p<0.001). P...Continue Reading

Citations

Mar 13, 2014·Oral Oncology·Iman SalahshourifarRosnah Binti Zain
Sep 23, 2014·Archives of Dermatological Research·Mônica Ghislaine Oliveira AlvesJanete Dias Almeida
Jun 22, 2021·Experimental and Therapeutic Medicine·Oana Mihaela Condurache HritcuElena Carmen Cotrutz

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