Retinoblastoma in a dog

Archives of Ophthalmology
N A SyedD M Albert

Abstract

To describe and classify a retinal tumor found in a dog that histologically resembles human retinoblastoma and to discuss the molecular mechanisms of retinal oncogenesis. A dog eye with a retinal tumor was examined histologically. Studies including immunocytochemical analysis for retinal S-antigen and glial fibrillary acidic protein, enzyme histochemical analysis for carbonic anhydrase, and nick-end DNA labeling were used to characterize the tumor. Normal retina from another dog and other tumors from dogs, including 2 ciliary body medulloepitheliomas and a brain medulloepithelioma, were examined as controls. The retinal tumor disclosed characteristics typical of human retinoblastoma, including Flexner-Wintersteiner rosettes. It showed strong immunoreactivity with S-antigen and glial fibrillary acidic protein. Carbonic anhydrase activity also could be shown in the tumor. Apoptosis was found to be the predominant method of cell death as shown by nick-end DNA labeling. In contrast to the other tumors examined, this tumor contained areas with retinal photoreceptor and glial differentiation. The histopathologic findings and differential staining characteristics in this retinal tumor are compatible with retinoblastoma, making this, t...Continue Reading

Citations

Aug 20, 2011·Genes & Development·Julien Sage, Andrea Ventura
Oct 30, 2004·Veterinary Ophthalmology·Mona AleksandersenSteffen Heegaard
Jul 13, 2005·Veterinary Ophthalmology·Michael N FugaroEvan B Janovitz
Mar 19, 2003·Veterinary Ophthalmology·Ove A JensenSteffen Heegaard
Nov 1, 2007·Veterinary Ophthalmology·Derek C KnottenbeltVeronica Roberts
Sep 25, 2010·Veterinary Ophthalmology·Susan L BartlettPaul R Bowser
May 17, 2013·Veterinary Ophthalmology·Daniel P ReganE J Ehrhart
Jun 12, 2013·Veterinary Ophthalmology·Caroline J Zeiss
Dec 14, 2011·Veterinary Pathology·P LabelleA L Labelle
Mar 31, 2010·Veterinary Pathology·R A KaganM J Kinsel
Mar 16, 2004·Veterinary Pathology·D K Meyerholz, J S Haynes
Nov 11, 2017·Clinical and Translational Medicine·Sonya StenfeltHenrik Boije
Aug 17, 2015·Veterinary Sciences·Timothy M Fan, Chand Khanna
Nov 17, 2007·Cancer Research·Lalita WadhwaRichard L Hurwitz
Jul 23, 1999·Survey of Ophthalmology·M D MillsD M Albert

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