PMID: 11907476Mar 22, 2002Paper

Retinoblastoma in older children

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Zeynel A KarciogluDelia H Pilapil

Abstract

Retinoblastoma (RB) is known to present with atypical signs and symptoms in older patients. Our article reviews the clinical and histopathological features of RB encountered in children older than 5 years of age. A total of 337 consecutive patients with RB were reviewed. Eighteen (5.3%; 10 males, 8 females) who presented after the age of 5 were selected for further analysis of clinical data and histopathological material in this retrospective, non-comparative case series. The age range was from 5 to 12 years (mean age 6.4). Unilateral disease was seen in 14 children, bilateral disease in 4 children. Eleven children were the product of consanguineous marriages. Seven patients had leukocoria; the others presented with signs of uveitis, cellulitis, and/or trauma. Three patients had flat, plaque-like lesions on histopathologic evaluation. Clinical and histopathologic features were atypical in 47% and 21% respectively in the retinoblastoma patients who presented after the age of 5 years.

Citations

Sep 22, 2007·AJNR. American Journal of Neuroradiology·P de GraafJ A Castelijns
Jun 3, 2009·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Scott D LawrenceBarrett G Haik
Jul 19, 2006·Pediatric Blood & Cancer·Joaquim Caetano de Aguirre NetoVictor Arias
Jun 11, 2015·The British Journal of Ophthalmology·Bhavna ChawlaR M Pandey
Feb 12, 2021·European Journal of Ophthalmology·Irving Armando Domínguez-VarelaDavid Ancona-Lezama
Feb 17, 2021·Postgraduate Medical Journal·Katerina LazariSofia Androudi
Apr 7, 2007·Journal of Pediatric Ophthalmology and Strabismus·Ramesh MurthyVijayanand P Reddy
Jan 16, 2021·Ocular Oncology and Pathology·Rachna MeelMeenakshi Wadhwani

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