Retinoblastoma protein expression in endometrial hyperplasia and carcinoma

Gynecologic Oncology
T H NiemannL Vaccarello

Abstract

The retinoblastoma (RB) gene was the first defined tumor suppressor gene. While originally described in retinoblastoma, more recently alterations in RB have been described in a number of other human neoplasms and there has been a suggestion that alteration of RB may play a significant role in the development of endometrial carcinoma. We examined RB protein expression by immunohistochemistry in a series of cases including normal endometrium, endometrial hyperplasia, and endometrial carcinoma. A relatively homogeneous pattern of staining was observed in proliferative endometrium, while weak or absent reactivity was noted in secretory endometrium. A heterogeneous pattern of reactivity was observed in 10/10 cases of hyperplasia, 66/70 cases of endometrial adenocarcinoma, and 7/7 cases of uterine carcinosarcoma. An altered pattern of reactivity was observed in the remaining 4/70 cases of adenocarcinoma. All of the cases with altered reactivity were high grade neoplasms. We conclude that alteration of RB protein expression is uncommon in endometrial adenocarcinoma and when it does occur, it may represent a late event in carcinogenesis.

References

Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F J KayeJ M Horowitz
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R BooksteinW H Lee
Mar 9, 1984·Science·A L Murphree, W F Benedict
Jul 15, 1994·International Journal of Cancer. Journal International Du Cancer·J GeradtsH J Xu

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Citations

Jun 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E IoachimM Salmas
Feb 16, 2000·Pathology, Research and Practice·A SemczukJ A Jakowicki
Aug 19, 2014·The Journal of Obstetrics and Gynaecology Research·Kouji BannoDaisuke Aoki
May 3, 2005·Gynecologic Oncology·Sokbom KangHyo Pyo Lee
Jul 2, 1998·Gynecologic Oncology·T H NiemannL J Copeland
Jun 1, 2000·Gynecologic Oncology·M J SchmitzM J Birrer
Jun 18, 2003·Journal of Cellular Physiology·Karin Milde-Langosch, Sabine Riethdorf
Dec 7, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Satoru KyoMasaki Inoue
Dec 13, 2003·Cancer Letters·Andrzej Semczuk, Jerzy Andrzej Jakowicki

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