Retinogenesis: stochasticity and the competency model

Journal of Theoretical Biology
A Barton, A J Fendrik

Abstract

The vertebrate retina is made up of seven principal cell types. These seven retinal cell types arise from multipotent retinal progenitor cells (RPCs). The competency model was proposed suggesting that RPCs undergo a series of irreversible transitions between competency states, in each of which the RPCs are competent to generate a different subset of cell types, but not retinal cells generated at previous moments. In this work, we generalize the stochastic model of neurogenesis of Barton et al. (2014), assuming that the same factor that regulates the differentiation, regulates the competency. The model reproduces the timing of production of different retinal cell types in rats such as it was experimentally measured. The results show that the evolution of the competency during retinogenesis could be explained by a single factor. Its evolution during the cell cycle and the stochastic inheritance in cell divisions determine the sequence and the overlap of production of different retinal cell types during development.

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Citations

Apr 12, 2016·Progress in Retinal and Eye Research·Paul A RobertsHelen M Byrne
Aug 22, 2016·Preventive Veterinary Medicine·Maud MarsotAurélie Courcoul
Aug 26, 2016·Molecular Neurobiology·Luana de Almeida-PereiraLucianne Fragel-Madeira
Mar 27, 2018·Molecular Neurobiology·Luana de Almeida-PereiraLucianne Fragel-Madeira
Oct 23, 2021·Frontiers in Cell and Developmental Biology·Xuhong ZhangYe Shen

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