PMID: 8950195Nov 15, 1996Paper

Retinoic acid affects the expression rate of the differentiation-related genes aryl hydrocarbon receptor, ARNT and keratin 4 in proliferative keratinocytes only

Biochimica Et Biophysica Acta
R WannerT Rosenbach

Abstract

The environmental contaminant dioxin exerts most of its effects by activating the aryl hydrocarbon receptor (AhR). The AhR is considered to play not only a role in the regulation of xenobiotic metabolism, but also for development, growth, and differentiation. The transcript levels of the AhR and its associated translocator protein (ARNT) were found to increase with ongoing differentiation in the human keratinocyte cell line HaCaT. Correspondingly, in situ hybridization studies in normal human skin revealed an absence of AhR-expression in proliferating basal cells and increasing transcript levels in upper cell layers, in dependence of keratinocyte differentiation. AhR expression in differentiation-deficient hyperproliferative psoriatic skin was markedly decreased. When keratinocytes were continuously treated with 1 microM retinoic acid (RA), the upregulation of AhR- and ARNT-mRNA levels was inhibited as was keratin 4-expression, a marker of HaCaT-keratinocyte differentiation. In contrast, treatment of already differentiated cells with RA did not down-regulate these transcript levels. The mRNA levels of the prevalent retinoic acid receptors in keratinocytes, RAR gamma and RXR alpha, were not influenced by the process of different...Continue Reading

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Citations

Feb 11, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·M E Hahn
Mar 25, 2014·Annual Review of Immunology·Brigitta StockingerJoão H Duarte
Jun 26, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fatemeh B RassouliMun Seng Kan
Jul 25, 2009·Drug Metabolism Reviews·Katalin MonostoryZdenek Dvorak
Oct 28, 2008·Expert Opinion on Drug Metabolism & Toxicology·Hitoshi AshidaItsuko Fukuda
Feb 25, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yan-Mei YangXu-Hong Song
Jun 20, 2002·Critical Reviews in Toxicology·Charlotte B Nilsson, Helen Håkansson

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