Retinoic acid and nitric oxide promote cell proliferation and differentially induce neuronal differentiation in vitro in the cnidarian Renilla koellikeri

Developmental Neurobiology
Djoyce Estephane, Michel Anctil

Abstract

Retinoic acid (RA) and nitric oxide (NO) are known to promote neuronal development in both vertebrates and invertebrates. Retinoic acid receptors appear to be present in cnidarians and NO plays various physiological roles in several cnidarians, but there is as yet no evidence that these agents have a role in neural development in this basal metazoan phylum. We used primary cultures of cells from the sea pansy Renilla koellikeri to investigate the involvement of these signaling molecules in cnidarian cell differentiation. We found that 9-cis RA induce cell proliferation in dose- and time-dependent manners in dishes coated with polylysine from the onset of culture. Cells in cultures exposed to RA in dishes devoid of polylysine were observed to differentiate into epithelium-associated cells, including sensory cells, without net gain in cell density. NO donors also induce cell proliferation in polylysine-coated dishes, but induce neuronal differentiation and neurite outgrowth in uncoated dishes. No other cell type undergoes differentiation in the presence of NO. These observations suggest that in the sea pansy (1) cell adhesion promotes proliferation without morphogenesis and this proliferation is modulated positively by 9-cis RA a...Continue Reading

References

Jun 1, 1995·Seminars in Cell Biology·V Schmid, S Reber-Müller
May 1, 1995·Journal of Neuroscience Research·K NeumanT Neuman
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G AllenbyP Chambon
Apr 30, 1993·Science·P P LefebvreT R Van de Water
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·T TakahashiT Sugiyama
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z KostrouchJ E Rall
Mar 31, 1999·Microscopy Research and Technique·V SchmidS Reber-Müller
Aug 24, 1999·Developmental Biology·Y Raz, M W Kelley
Sep 9, 1999·In Vitro Cellular & Developmental Biology. Animal·J A UlibarriT M Best
Jun 5, 2003·Molecular Neurobiology·Sarah M Gibbs
Jul 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael A PackerGrigori Enikolopov
Aug 12, 2003·The Journal of Experimental Biology·Matthias WiensWerner E G Müller
Feb 26, 2004·The Journal of Comparative Neurology·Leonid L MorozGeorge O Mackie
Mar 11, 2004·The European Journal of Neuroscience·Kevin R Trimm, Vincent Rehder
Mar 30, 2004·The Journal of Comparative Neurology·Vincent PernetCornelis J P Grimmelikhuijzen
Apr 28, 2004·Developmental Biology·Leigh WilsonMalcolm Maden
Sep 15, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Katka SeipelVolker Schmid
Oct 7, 2004·Developmental Biology·Dominique GauchatBrigitte Galliot
May 10, 2005·The Journal of Experimental Biology·Michel AnctilClaudine Pelletier
Aug 3, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Carmen Estrada, Maribel Murillo-Carretero
Dec 17, 2005·Molecular Genetics and Metabolism·Joshua S Krumenacker, Ferid Murad
Apr 22, 2006·Developmental Biology·Jennifer M DmetrichukGaynor E Spencer
Jun 30, 2006·Seminars in Cell & Developmental Biology·Brigitte GalliotSimona Chera
Jan 24, 2007·Development Genes and Evolution·David Q MatusMark Q Martindale
Aug 25, 2007·Developmental Biology·Jens H FritzenwankerUlrich Technau
Sep 21, 2007·Nature Reviews. Neuroscience·Malcolm Maden
May 10, 2008·BMC Evolutionary Biology·Brent A KnackDavid J Miller
Jun 25, 2008·The Biological Bulletin·Craig R Magie, Mark Q Martindale
Nov 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer M DmetrichukGaynor E Spencer

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Citations

Aug 19, 2014·General and Comparative Endocrinology·A AndréM M Santos
Jun 28, 2016·Biochemical and Biophysical Research Communications·Yadong ZhangHongzhang Huang
Mar 2, 2018·Science Advances·Mette Handberg-ThorsagerMichael Schubert
Mar 4, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Natália HvizdošováDarina Kluchová
Jan 15, 2021·Genes·Angelica MiglioliRémi Dumollard

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