Retinoic acid-driven Hox1 is required in the epidermis for forming the otic/atrial placodes during ascidian metamorphosis

Development
Yasunori SasakuraShigeki Fujiwara

Abstract

Retinoic acid (RA)-mediated expression of the homeobox gene Hox1 is a hallmark of the chordate central nervous system (CNS). It has been suggested that the RA-Hox1 network also functions in the epidermal ectoderm of chordates. Here, we show that in the urochordate ascidian Ciona intestinalis, RA-Hox1 in the epidermal ectoderm is necessary for formation of the atrial siphon placode (ASP), a structure homologous to the vertebrate otic placode. Loss of Hox1 function resulted in loss of the ASP, which could be rescued by expressing Hox1 in the epidermis. As previous studies showed that RA directly upregulates Hox1 in the epidermis of Ciona larvae, we also examined the role of RA in ASP formation. We showed that abolishment of RA resulted in loss of the ASP, which could be rescued by forced expression of Hox1 in the epidermis. Our results suggest that RA-Hox1 in the epidermal ectoderm played a key role in the acquisition of the otic placode during chordate evolution.

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Citations

Oct 9, 2013·EvoDevo·Linda Z HollandJr-Kai Yu
Feb 4, 2016·Cell and Tissue Research·Satoshi NakayamaMichio Ogasawara
Oct 18, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Akiko HozumiYasunori Sasakura
Jan 11, 2013·Development, Growth & Differentiation·Miyuki KandaShigeki Fujiwara
Sep 13, 2014·Development, Growth & Differentiation·Haruka SasakiYasunori Sasakura
Mar 31, 2015·Current Opinion in Genetics & Development·Nicole KaplanLionel Christiaen
Nov 15, 2014·Genesis : the Journal of Genetics and Development·Fabio CrocettaPaolo Sordino
Sep 16, 2014·Genesis : the Journal of Genetics and Development·Alberto StolfiPatrick Lemaire
Oct 15, 2013·Developmental Biology·Kaz KawamuraShigeki Fujiwara
Jan 8, 2013·Seminars in Cell & Developmental Biology·Cristian CañestroJordi Garcia-Fernàndez
Apr 19, 2015·Developmental Biology·Narudo KawaiYasunori Sasakura
Jan 8, 2013·Seminars in Cell & Developmental Biology·Linda Z Holland
Feb 2, 2018·Cellular and Molecular Life Sciences : CMLS·Elisabeth ZiegerMichael Schubert
Aug 8, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Akiko HozumiYasunori Sasakura
Sep 25, 2014·Genesis : the Journal of Genetics and Development·Anthi KaraiskouJean-Philippe Chambon
Aug 5, 2017·Wiley Interdisciplinary Reviews. Developmental Biology·Hugo J Parker, Robb Krumlauf
Jan 14, 2018·Genesis : the Journal of Genetics and Development·Aditi DubeyJean-Pierre Saint-Jeannet
Nov 7, 2017·Wiley Interdisciplinary Reviews. Developmental Biology·Yasunori Sasakura, Akiko Hozumi
Nov 5, 2019·Developmental Biology·Yukako TajimaYasunori Sasakura

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