Retinoic Acid Embryopathy

International Journal of Applied & Basic Medical Research
Dipankar MondalSantisena Mishra

Abstract

Isotretinoin is a retinoid which is derived from Vitamin A. It is indicated for severe cystic acne treatment, but it has been classified as teratogenic. A wide spectrum of birth defects including craniofacial, heart, and nervous system malformations have been described with prenatal exposure to this drug. We report the case of a newborn with a history of prenatal exposure to isotretinoin with craniofacial defects, including left-sided anotia, right-sided microtia, complex congenital heart disease, and central nervous system malformation.

References

Apr 1, 1992·Journal of the American Academy of Dermatology·W S DaiR S Stern
Apr 13, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·H Maradit, J M Geiger

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Citations

Mar 29, 2019·Expert Review of Vaccines·Sunita KeshariChun-Ming Huang
Jun 4, 2019·Journal of Developmental Biology·Eliyahu Perl, Joshua S Waxman
Jan 12, 2020·Birth Defects Research·Santiago CerrizuelaManuel J Aybar
Aug 2, 2020·Molecular Genetics & Genomic Medicine·Angèle Tingaud-SequeiraCaroline Rooryck
Aug 1, 2020·Journal of Cardiovascular Translational Research·Marlon De ItaHaydeé Rosas-Vargas
Jan 23, 2021·Antioxidants·Giovanni TossettaDaniela Marzioni

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Methods Mentioned

BETA
cesarean section
X-ray
contraception
pregnancy test

Software Mentioned

IPLEDGE

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Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

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