Retinoic acid in patients with radioiodine non-responsive thyroid carcinoma

Journal of Endocrinological Investigation
Sabrina Mendes CoelhoMário Vaisman

Abstract

De-differentiated thyroid carcinoma is characterized by loss of thyroid-specific functions and properties. The therapeutic options for this type of thyroid cancer are limited and generally not efficient. Recent studies with retinoic acid (RA) have shown that this drug can induce re-differentiation of the thyrocyte and tumor regression after 131I therapy. The aim of the present study was to assess the effects of RA therapy in patients with extensive thyroid tumor involvement, which lost radioiodine uptake ability. A total of 5 patients (1 follicular carcinoma, 3 papillary carcinomas and 1 poorly differentiated carcinoma) were treated with isotretinoin (1.0 to 1.5 mg/kg/day) for 5 weeks and then submitted to radioiodine therapy. Three parameters for assessment of RA effects were established: a) reduction of serum thyroglobulin levels; b) increment of the post-therapeutic dose radioiodine uptake; c) tumor size regression after therapy. All patients completed the treatment and the most frequent side effects were dry skin and lips and hypertriglyceridemia. One patient showed satisfactory response (2 or more of the 3 criteria were reached) and a new cycle of RA was given. In two, just a partial response (1 criterion) was seen and the...Continue Reading

References

Sep 1, 1990·The Journal of Clinical Endocrinology and Metabolism·A J Van HerleG J Juillard
Oct 1, 1987·Annals of Internal Medicine·S M Lippman, F L Meyskens
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·D SimonH D Röher
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·C SchmutzlerJ Köhrle
Jan 29, 1998·The New England Journal of Medicine·M J Schlumberger
Jan 16, 1999·Seminars in Surgical Oncology·B R Haugen
Jul 7, 2000·Thyroid : Official Journal of the American Thyroid Association·C Schmutzler, J Köhrle
Sep 21, 2001·The Histochemical Journal·E FröhlichR Wahl
May 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·D SimonC Reiners
Jun 1, 2002·Molecular and Cellular Endocrinology·C SchmutzlerJ Köhrle

❮ Previous
Next ❯

Citations

Aug 17, 2006·Thyroid : Official Journal of the American Thyroid Association·Lisa K GilliamCheryl A Pickett
Oct 18, 2006·Thyroid : Official Journal of the American Thyroid Association·F CourbonPh Caron
Sep 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Ana Luiza MaiaMario Vaisman
Feb 11, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Katherine A AraqueJoanna Klubo-Gwiezdzinska
Sep 27, 2005·Arquivos brasileiros de endocrinologia e metabologia·Pedro Weslley S RosárioSaulo Purisch
Oct 25, 2007·Thyroid : Official Journal of the American Thyroid Association·Sabrina Mendes CoelhoMário Vaisman
Aug 9, 2007·Arquivos brasileiros de endocrinologia e metabologia·Sabrina Mendes CoelhoMário Vaisman
Nov 19, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S M CoelhoM Vaisman
May 4, 2016·Current Treatment Options in Oncology·Sujata Narayanan, A Dimitrios Colevas
Sep 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Denise P Carvalho, Andrea C F Ferreira
Nov 23, 2006·Acta Oncologica·Gertrud Berg
Jun 11, 2009·Journal of Endocrinological Investigation·L LanH Wang
Feb 15, 2013·The New England Journal of Medicine·Alan L HoJames A Fagin
Jun 14, 2013·Thyroid : Official Journal of the American Thyroid Association·Sun Wook ChoYoung Joo Park
Mar 15, 2015·The Journal of Clinical Endocrinology and Metabolism·Maomei RuanLibo Chen
Jul 6, 2014·Clinical Endocrinology·Petros PerrosUNKNOWN British Thyroid Association
Aug 2, 2013·European Journal of Endocrinology·Ana Paula VidalDenise P Carvalho
Jul 28, 2018·Journal of the National Cancer Institute·Moran AmitZiv Gil
Oct 11, 2019·Current Opinion in Oncology·Stefania BulottaDiego Russo
Dec 25, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Eleonore FröhlichRichard Wahl
Jul 6, 2013·Arquivos brasileiros de endocrinologia e metabologia·Pedro Weslley RosárioUNKNOWN Sociedade Brasileira de Endocrinologia e Metabologia
Sep 8, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael C KreisslJames Nagarajah
Jan 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E KapiteijnJ W A Smit
Feb 24, 2009·Life Sciences·Alba Cenélia M SilvaAndrea C F Ferreira
Feb 24, 2010·Molecular Aspects of Medicine·Maria Graziella CatalanoGiuseppe Boccuzzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.