Retinoic acid-induced protein ISGylation is dependent on interferon signal transduction

Blood Cells, Molecules & Diseases
Chinh T DaoDong-Er Zhang

Abstract

Interferon-stimulated gene 15 (ISG15) is a ubiquitin-like modifier that forms conjugates with target protein substrates. As its name suggests, its expression and conjugation to other proteins are highly regulated by interferon (IFN). It was recently demonstrated that ISG15 expression, ISG15 conjugation, and several enzymes involved in ISG15 modification are upregulated in an acute promyelocytic cell line following treatment with retinoic acid, suggesting a possible retinoic acid induced IFN-independent ISG15 modification pathway. In this study, we examined a possible link between IFN signaling and retinoic acid-induced ISG15 conjugation. We observed that ISGylation can be induced by retinoic acid in two myeloid leukemia cell lines. By sandwich ELISA, we detected increased IFN secretion into cell culture media following retinoic acid treatment. Blockade of the type I IFN receptor with a neutralizing antibody blocked retinoic acid induced ISG15 expression and ISG15 conjugation. Taken together, these data suggested that retinoic acid-induced secretion of IFN plays a fundamental role in retinoic acid promoted ISGylation.

References

Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D S KesslerJ E Darnell
Oct 6, 1995·The Journal of Biological Chemistry·G A DeblandreM G Wathelet
Nov 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M S Künzi, P M Pitha
Sep 12, 1997·Science·J E Darnell
Jul 11, 1998·Molecular Cell·H HermekingB Vogelstein
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·S D DerR H Silverman
Feb 27, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J HiscottR Lin
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·J ZhuH de Thé
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·C H YangL M Pfeffer
Jan 3, 2001·Journal of Virology·K L MossmanJ R Smiley
Feb 24, 2001·Annals of the New York Academy of Sciences·S D DesaiL F Liu
Jun 8, 2001·Annual Review of Biochemistry·C M Pickart
Jan 15, 2002·The Journal of Biological Chemistry·Michael P MalakhovDong-Er Zhang
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tomohiko Tamura, Keiko Ozato
Feb 21, 2002·The Journal of Biological Chemistry·Oxana MalakhovaDong-Er Zhang
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sutisak KitareewanEthan Dmitrovsky
Oct 2, 2002·The Journal of Biological Chemistry·Sun-Young HanLynn E Heasley
Feb 21, 2004·The Journal of Biological Chemistry·Ian Pitha-RoweEthan Dmitrovsky
May 8, 2004·The Journal of Biological Chemistry·Lawrence M PfefferRamin Homayouni
May 8, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chen ZhaoRobert M Krug
Oct 16, 2004·Molecular and Cellular Biology·Keun Il KimDong-Er Zhang
Nov 9, 2004·Nature Medicine·Kenneth J RitchieDong-Er Zhang
Feb 3, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mingjuan LiuBret A Hassel
Jun 23, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Chinh T Dao, Dong-Er Zhang
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keun Il KimDong-Er Zhang

❮ Previous
Next ❯

Citations

Dec 31, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Dongxian Zhang, Dong-Er Zhang
Jan 29, 2011·Gastroenterology Research and Practice·Helene Minyi Liu, Michael Gale
Apr 17, 2008·Molecular Cancer Therapeutics·Sumit J ShahEthan Dmitrovsky
Jun 21, 2008·Molecular Cancer Therapeutics·Shyamal D DesaiLeroy F Liu
Apr 8, 2010·Cellular and Molecular Life Sciences : CMLS·Yvonne G J van HeldenJaap Keijer
Aug 11, 2007·Cytokine & Growth Factor Reviews·Ian F Pitha-Rowe, Paula M Pitha
Sep 18, 2007·Journal of Cellular Biochemistry·Sarah J FreemantleEthan Dmitrovsky
Feb 5, 2015·Journal of Cellular Biochemistry·Apei JiangQing Feng
May 18, 2018·Nature Reviews. Microbiology·Yi-Chieh Perng, Deborah J Lenschow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.