PMID: 3772160Nov 1, 1986Paper

Retinoic acid induces cyclic changes in epidermal thickness and dermal collagen and glycosaminoglycan biosynthesis rates

The Journal of Investigative Dermatology
J R SchiltzJ E Birnbaum

Abstract

The effects of daily topical application onto guinea pig ears of a therapeutic concentration of all trans-retinoic acid (RA) on epidermal thickness and dermal collagen and glycosaminoglycan (GAG) biosynthesis rates were studied during a 40-day period. Clinically, the RA-treated skin became erythematous and scaly beginning at 5-6 days, conditions which persisted throughout the experiment. The epidermis became thickened and hyperplastic with marked psoriasi-form histologic features, and the phenomenon was dependent on RA concentration. The initial hyperplasia resulted from a transient 4-fold increase in epidermal basal cell replication during the first 3-4 days, as shown by the rise and fall of [3H]thymidine labeling index which preceded the hyperplasia. The extent of epidermal hyperplasia as measured by epidermal thickness was not constant throughout the 40-day treatment period, but exhibited maxima on days 11, 25, and 36. These maxima were followed by periods of decreased thickness, although the minima were always greater than the untreated controls. Retinoic acid induced similar temporal cycles in GAG and collagen biosynthesis rates, but the collagen cycles occurred at different times with maxima on days 6, 20, and 34. After 8...Continue Reading

Citations

Apr 1, 1994·Australian Dental Journal·T A WinningN W Savage
Feb 22, 2012·Clinical and Experimental Dermatology·D M Z ValentiS B V Mello
Aug 2, 2012·American Journal of Clinical Dermatology·Lauren L Levy, Joshua A Zeichner
Apr 1, 1989·European Journal of Clinical Investigation·S Hirschel-ScholzJ H Saurat
Jan 1, 1995·International Journal of Dermatology·J B SchmidtC Bieglmayer
Apr 1, 1990·The British Journal of Dermatology·E BerardescaG Rabbiosi
Apr 7, 1999·International Journal of Dermatology·J B SchmidtA Reiner
Oct 14, 2017·International Journal of Toxicology·Wilbur Johnson

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