Retinoic acid induces neurite outgrowth and growth cone turning in invertebrate neurons

Developmental Biology
J M DmetrichukG E Spencer

Abstract

Identification of molecules involved in neurite outgrowth during development and/or regeneration is a major goal in the field of neuroscience. Retinoic acid (RA) is a biologically important metabolite of vitamin A that acts as a trophic factor and has been implicated in neurite outgrowth and regeneration in many vertebrate species. Although abundant in the CNS of many vertebrates, the precise role of RA in neural regeneration has yet to be determined. Moreover, very little information is available regarding the role of RA in invertebrate nervous systems. Here, we demonstrate for the first time that RA induces neurite outgrowth from invertebrate neurons. Using individually identified neurons isolated from the CNS of Lymnaea stagnalis, we demonstrated that a significantly greater proportion of cells produced neurite outgrowth in RA. RA also extended the duration of time that cells remained electrically excitable in vitro, and we showed that exogenously applied RA acted as a chemoattractive factor and induced growth cone turning toward the source of RA. This is the first demonstration that RA can induce turning of an individual growth cone. These data strongly suggest that the actions of RA on neurite outgrowth and cell survival a...Continue Reading

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J P Brockes
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K HunterN Holder
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L WuarinJ de Vellis
May 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R M Eakin, J L Brandenburger
Apr 1, 1994·Developmental Biology·S R Scadding, M Maden
May 31, 1996·Brain Research. Developmental Brain Research·M YamamotoU C Dräger
Nov 15, 1996·Science·M Tessier-Lavigne, C S Goodman
Oct 1, 1996·Cellular and Molecular Neurobiology·G E SpencerN I Syed
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·S G MansfieldW E Bollenbacher
Jun 27, 1998·Biochemical and Biophysical Research Communications·Z Y GaoB A Wolf
Oct 6, 1998·Nature·L SolominT Perlmann
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z KostrouchJ E Rall
Nov 26, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M MadenG E Jones
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·D Q Zhang, D G McMahon
Aug 31, 2002·Development Genes and Evolution·Diana DalfóRoser Gonzàlez-Duarte
Sep 18, 2002·Journal of Cell Science·Jonathan CorcoranMalcolm Maden
Jan 14, 2003·Brain Research. Developmental Brain Research·David J Prince, Robert L Carlone
Jan 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Malcolm Maden, Matthew Hind
Jul 23, 2003·Biochemistry·Wendy F OchoaJuan C Gomez-Fernandez
Aug 12, 2003·The Journal of Experimental Biology·Matthias WiensWerner E G Müller
Sep 11, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jörg Mey, Peter McCaffery
Sep 17, 2004·Molecular Biology of the Cell·Estela CañónAna Aranda
Mar 15, 2005·Critical Reviews in Biochemistry and Molecular Biology·David S Garbe, Greg J Bashaw
Apr 26, 2005·Developmental Biology·Jennifer M DmetrichukRobert L Carlone
Aug 22, 2007·Trends in Cell Biology·S McFarlane, C E Holt

❮ Previous
Next ❯

Citations

Dec 7, 2007·PPAR Research·Sabien van Neerven, Jörg Mey
Aug 12, 2014·Cell and Tissue Research·Jeyathevy SukibanKatrin Bui-Göbbels
Feb 9, 2010·Cellular and Molecular Life Sciences : CMLS·Maria TheodosiouMichael Schubert
Mar 13, 2013·Cellular and Molecular Life Sciences : CMLS·Nicola Blum, Gerrit Begemann
Feb 19, 2008·The European Journal of Neuroscience·Kwokyin Hui, Zhong-Ping Feng
Nov 13, 2008·Genesis : the Journal of Genetics and Development·Florent Campo-PaysaaMichael Schubert
May 4, 2016·Tissue Barriers·Nienke R Wevers, Helga E de Vries
Dec 17, 2014·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Christopher J CarterGaynor E Spencer
Jun 14, 2014·Neurobiology of Learning and Memory·Cailin M Rothwell, Gaynor E Spencer
Apr 26, 2008·Developmental Biology·Nathan R Farrar, Gaynor E Spencer
Jul 8, 2008·Developmental Biology·Guoying Wang, Sheryl A Scott
Nov 18, 2016·Journal of Neurophysiology·Cailin M RothwellGaynor E Spencer
Nov 17, 2006·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Marcos S Simões-CostaJosé Xavier-Neto
Aug 15, 2014·Endocrinology·Juliana Gutierrez-MazariegosVincent Laudet
Dec 29, 2013·Journal of Neurophysiology·Nicholas D Vesprini, Gaynor E Spencer
Oct 25, 2014·Journal of Neurophysiology·Nicholas D VespriniGaynor E Spencer
Mar 13, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Diogo TrigoJonathan P T Corcoran
Sep 16, 2018·International Journal of Molecular Sciences·Sarah E WalkerRobert L Carlone
May 1, 2019·Genesis : the Journal of Genetics and Development·Alysha JohnsonGaynor E Spencer
Oct 24, 2020·Cellular and Molecular Neurobiology·Sarah E WalkerGaynor E Spencer
Dec 1, 2009·The Journal of Experimental Biology·F WolschinG V Amdam
Jul 28, 2021·Progress in Neurobiology·Nasim Bahram SanganiChris P Reutelingsperger
Oct 3, 2021·Nature·Mikihito ShibataNenad Sestan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

Related Papers

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
M MadenG E Jones
© 2022 Meta ULC. All rights reserved