Retinoic acid is required early during adult neurogenesis in the dentate gyrus

Proceedings of the National Academy of Sciences of the United States of America
Sharoni JacobsRonald M Evans

Abstract

Retinoic acid (RA) is commonly used in vitro to differentiate stem cell populations including adult neural stem cells into neurons; however, the in vivo function of RA during adult neurogenesis remains largely unexplored. We found that depletion of RA in adult mice leads to significantly decreased neuronal differentiation within the granular cell layer of the dentate gyrus. RA contribution to neurogenesis occurs early, for RA deficiency also results in a decrease in newborn cells expressing an immature neuronal marker. Furthermore, although proliferation is unaffected during RA absence, cell survival is significantly reduced. Finally, a screen for retinoid-induced genes identifies metabolic targets including the lipid transporters, CD-36 and ABCA-1, the lipogenic master regulator SREBP1c as well as components of the Wnt signaling pathway. Our results reveal RA as a crucial contributor to early stages of adult neurogenesis and survival in vivo.

References

Mar 1, 1992·Genes & Development·D J MangelsdorfR M Evans
Dec 17, 1987·Nature·V GiguereR M Evans
Dec 15, 1995·Cell·D J MangelsdorfR M Evans
May 24, 1996·The Journal of Biological Chemistry·C AgarwalR L Eckert
Jan 24, 1998·Developmental Biology·F R Lucas, P C Salinas
Mar 14, 1998·Developmental Biology·C Chang, A Hemmati-Brivanlou
Aug 26, 1998·Journal of Neurobiology·F H GageJ Ray
Sep 16, 1999·Biochemical and Biophysical Research Communications·D S DesaiS Ohno
Sep 29, 1999·The American Journal of Clinical Nutrition·R M PonnamperumaL M De Luca
Feb 26, 2000·Science·F H Gage
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D M WuttgeA Sirsjö
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·D L MisnerR M Evans
Feb 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Elizabeth A Werner, Hector F Deluca
Apr 12, 2002·Brain Research. Developmental Brain Research·Gerd Kempermann, Fred H Gage
Apr 12, 2002·Brain Research. Developmental Brain Research·Christiana M Cooper-Kuhn, H Georg Kuhn
Nov 5, 2002·Nature Reviews. Neuroscience·Malcolm Maden
May 20, 2003·The European Journal of Neuroscience·Dongmei WuTohru Kataoka
Oct 16, 2003·Molecular and Cellular Biology·Philippe CostetAlan R Tall
Dec 13, 2003·Neurobiology of Learning and Memory·Jos PrickaertsArjan Scheepens
Oct 28, 2005·Nature·Dieter-Chichung LieFred H Gage

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Citations

Dec 24, 2011·Psychopharmacology·Anthony D OrmerodPeter J A McCaffery
Mar 22, 2012·European Archives of Psychiatry and Clinical Neuroscience·Julian Hellmann-RegenGolo Kronenberg
Sep 18, 2012·Nature Neuroscience·Randolph S AshtonDavid V Schaffer
Dec 9, 2010·The Journal of Biological Chemistry·Chao WangJoseph L Napoli
Oct 17, 2012·The Journal of Biological Chemistry·Jakob A ShimshoniNina Isoherranen
Jun 20, 2008·Stem Cells and Development·Elena AnghileriBruno Bonetti
Jun 6, 2013·Stem Cells and Development·Barbara OrsolitsZsuzsanna Környei
Jul 27, 2012·British Medical Bulletin·Muhammad Syahrul Anwar Zainuddin, Sandrine Thuret
Sep 24, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yanhua LinRobert E Marc
Dec 20, 2007·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Jenny Libien, William S Blaner
Apr 28, 2011·Molecular Pharmacology·Jayne E ThatcherNina Isoherranen
Apr 27, 2010·Annual Review of Nutrition·Noa Noy
Mar 18, 2008·Neurosurgical Focus·Haviryaji S G Kalluri, Robert J Dempsey
Nov 22, 2013·Stem Cells International·Nobuyuki SakayoriNoriko Osumi
Feb 22, 2014·CNS Drugs·Yara Dadalti FragosoPeter J McCaffery
Nov 15, 2011·Brain Structure & Function·Yara Dadalti FragosoPeter J McCaffery
Sep 28, 2014·BMC Cancer·Padmamalini ThulasiramanImran Q Mohiudddin
Aug 22, 2006·Expert Opinion on Biological Therapy·Kurt A SailorHongjun Song
Jun 13, 2009·Expert Opinion on Drug Metabolism & Toxicology·Jayne E Thatcher, Nina Isoherranen
Sep 14, 2013·The Journal of Nutritional Biochemistry·Deborah R Morris, Cathy W Levenson
Feb 7, 2013·Journal of Neuroimmunology·Julian Hellmann-RegenKaren Gertz
Sep 11, 2012·Trends in Neurosciences·Kirsty D ShearerPeter J McCaffery
Jan 12, 2016·Molecular Neurobiology·Sukhleen Kour, Pramod C Rath
Mar 18, 2010·The Journal of Nutritional Biochemistry·Hui-Min Su
Feb 16, 2010·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·C J ChávezL E Miranda
Aug 26, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chunling WanLin He
Jun 23, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C MartinA Gato
May 20, 2015·Developmental Neurobiology·Jessica T ChangHazel Sive
Aug 21, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Douglas Bremner, Peter McCaffery
May 22, 2007·Neurobiology of Aging·Jonathan Brouillette, Rémi Quirion
May 4, 2007·Current Opinion in Neurobiology·Jovica Ninkovic, Magdalena Götz

❮ Previous
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