PMID: 8601734Feb 1, 1996Paper

Retinoic acid isomers applied to human skin in vivo each induce a 4-hydroxylase that inactivates only trans retinoic acid

The Journal of Investigative Dermatology
E A DuellJ J Voorhees

Abstract

Application of all-trans retinoic acid to human skin for 4 d under occlusion produces a marked increase in retinoic acid 4-hydroxylase activity. In this study, the possible induction of other hydroxylase in response to 9-cis and 13-cis retinoic acid application to adult human skin in vivo was determined. Application of 0.1% all-trans, 0.1% 9-cis, and 0.1% 13-cis retinoic acid to human skin for 2 d resulted in induction of only all-trans retinoic acid 4-hydroxylase activity. The 4-hydroxylase activity in microsomes from the treated tissue ranged from 838 +/- 46 to 531 +/- 59 pg of 4- hydroxy all-trans retinoic acid formed/min/mg protein (n=6). These same preparations were unable to use 9-cis or 13-cis retinoic acid as substrate for the hydroxylation reaction. Extraction of the retinoic acid isomers from epidermis 48 h after application of 0.1% solution of each isomer yielded significant amounts of all-trans retinoic acid (36-72%) regardless of the isomer applied. The all-trans isomer produced by isomerization of both 9-cis and 13-cis retinoic acids is the likely inducer of the 4-hydroxylase. All-trans retinol and all-trans retinal were unable to compete with all-trans retinoic acid as substrate for 4-hydroxylase enzyme. The 4-hy...Continue Reading

References

Jan 1, 1988·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·H Vanden BosscheP A Janssen
Feb 15, 1989·Archives of Biochemistry and Biophysics·M A LeoC S Lieber
Mar 1, 1994·Journal of the American Academy of Dermatology·P BuchanH Schaefer

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Citations

Jan 15, 2003·Human Reproduction·Fu-Jen HuangYan-Der Hsuuw
Aug 24, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·C J VerfailleP C M van de Kerkhof
Jan 6, 2004·The Journal of Nutrition·A Catharine Ross, Reza Zolfaghari
Mar 26, 2002·Biochemical Pharmacology·Julie MarillGuy G Chabot
Sep 14, 1999·Biochemical Pharmacology·L Nadin, M Murray
Sep 18, 1998·The Journal of Investigative Dermatology·R K Randolph, M Simon
Mar 6, 2003·Molecular Genetics and Metabolism·Nedialka G MarkovaM Simon
May 8, 2003·Journal of the American Academy of Dermatology·Lynn K PershingVinod P Shah
Apr 14, 2005·Biochemical Pharmacology·Jane L ArmstrongGareth J Veal

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