PMID: 9450139Feb 5, 1998Paper

Retinoic acid modulation of induced basophil differentiation

Allergy
B Leber, J A Denburg

Abstract

Current models of the regulation of hematopoiesis postulate a combination of both factor-directed cell differentiation/survival acting through intracellular signaling pathways, and factor-independent differentiation along intrinsically set, default pathways. Recent reports have indicated that eosinophil/basophil (Eo-Baso) differentiation may represent one default pathway. Because of the strong modulating effect of all trans-retinoic acid (ATRA) on hematopoietic differentiation, we have investigated the role of ATRA in regulating Eo-Baso differentiation from pluripotent progenitors. Our results indicate that ATRA inhibits Eo-Baso maturation at early stages of lineage commitment. Because allergic responses may depend on the continued recruitment and differentiation of such inflammatory mediators, the ability to modulate this pathway may eventually prove to have a therapeutic role in allergic inflammation.

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Citations

Jul 9, 2004·Toxicology and Applied Pharmacology·Richard H FinnellThomas H Rosenquist
May 20, 1999·Annual Review of Pharmacology and Toxicology·M D Collins, G E Mao
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Richard H FinnellThomas H Rosenquist
Mar 12, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Brandeis M McBratneyScott Lozanoff
Nov 28, 2008·British Journal of Haematology·Yosuke MasamotoMineo Kurokawa
May 9, 2014·Allergology International : Official Journal of the Japanese Society of Allergology·Shigeharu UekiJunichi Chihara
Apr 25, 2015·Nature Reviews. Immunology·Valerie JuliaDavid Dombrowicz
Mar 1, 1996·Allergy·J A DenburgP M O'Byrne
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shigeharu UekiJunichi Chihara
Feb 13, 2021·Frontiers in Immunology·Drishti Tiwari, Pawan Gupta

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Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.