Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in beta-amyloid deposits in the cerebral cortex of vitamin A deprived rats

Neurobiology of Disease
Marianne HussonPaul Higueret

Abstract

Recent data have revealed that disruption of vitamin A signaling observed in Alzheimer's disease (AD) leads to a deposition of beta-amyloid (Abeta). The aim of this study was to precise the role of vitamin A and its nuclear receptors (RAR) in the processes leading to the Abeta deposits. Thus, the effect of vitamin A depletion and subsequent administration of retinoic acid (RA, the active metabolite of vitamin A) on the expression of RARbeta, and of proteins involved in amyloidogenic pathway, e.g., amyloid precursor protein (APP), beta-secretase enzyme (BACE), and APP carboxy-terminal fragment (APP-CTF) was examined in the whole brain, hippocampus, striatum, and cerebral cortex of rats. Rats fed a vitamin A-deprived diet for 13 weeks exhibited decreased amount of RARbeta, APP695, BACE, and of APP-CTF in the whole brain and in the cerebral cortex. Administration of RA is able to restore all expression. The results suggest that fine regulation of vitamin A mediated gene expression seems fundamental for the regulation of APP processing.

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A Y HungD J Selkoe
Aug 31, 1990·Biochemical and Biophysical Research Communications·K YoshikawaK Maruyama
Jan 1, 1990·Brain Research. Molecular Brain Research·B A YanknerR L Neve
Dec 1, 1994·Brain Research. Molecular Brain Research·M A IñiguezJ Bernal
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·P McCaffery, U C Dräger
Oct 25, 1996·Mechanisms of Ageing and Development·H K Edelberg, J Y Wei
Jan 19, 2000·Progress in Neurobiology·J C VickersG McCormack
Jul 27, 2000·The British Journal of Nutrition·S BonillaP Higueret
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·D L MisnerR M Evans
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y Gao, S W Pimplikar
Apr 12, 2002·Journal of Neurochemistry·Ursula BodendorfPaolo Paganetti
Jul 12, 2002·Annals of Neurology·R M Damian HolsingerGeneviève Evin
Jul 23, 2002·The Proceedings of the Nutrition Society·Michael GrundmanPatrick Delaney
Sep 6, 2002·European Journal of Endocrinology·Chiara FiorentiniCristina Missale
Nov 20, 2002·Neuroreport·Luisa Benerini GattaDario Finazzi
Dec 11, 2002·The Journal of Biological Chemistry·Shinobu KitazumeYasuhiro Hashimoto
Feb 7, 2003·Current Drug Metabolism·Julie MarillGuy G Chabot
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ann B Goodman, Arthur B Pardee
Jun 26, 2003·Brain Research. Molecular Brain Research·Ofer ZoharDaniel L Alkon
Aug 29, 2003·Cellular and Molecular Life Sciences : CMLS·M L BonetA Palou
Nov 5, 2003·Journal of Neuroscience Research·Geneviève EvinQiao-Xin Li
Jan 27, 2004·The American Journal of Pathology·Hiroaki FukumotoMichael C Irizarry

❮ Previous
Next ❯

Citations

Nov 6, 2012·Nature Reviews. Drug Discovery·Anne CorbettClive Ballard
Nov 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yun DingGuo-Huang Fan
Mar 4, 2014·Pharmacology, Biochemistry, and Behavior·Rupinder K Sodhi, Nirmal Singh
Nov 15, 2011·Brain Structure & Function·Yara Dadalti FragosoPeter J McCaffery
Jul 22, 2009·The Journal of Nutrition, Health & Aging·Y Ingenbleek
Sep 29, 2012·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Asma ArfaouiMaría I Arenas
May 26, 2012·Cellular Signalling·Sylvie ClaeysenPatrizia Giannoni
Dec 31, 2010·The Journal of Nutritional Biochemistry·Ming ZhangChunling Wan
Apr 11, 2015·The British Journal of Nutrition·Rhona CreeganStephanie R Rainey-Smith
May 12, 2017·Expert Review of Neurotherapeutics·Ayesha KhanClive Ballard
Sep 21, 2007·Nature Reviews. Neuroscience·Malcolm Maden
Nov 12, 2009·Expert Review of Neurotherapeutics·Hyun-Pil LeeAlan Lerner
Oct 16, 2019·Journal of Neuroendocrinology·Damien BonhommeKatia Touyarot
Dec 20, 2015·Journal of Alzheimer's Disease : JAD·Mrinmay ChakrabartiSwapan K Ray
Nov 20, 2016·Journal of Molecular Neuroscience : MN·Niyaz Mohammadzadeh HonarvarGerald Muench
Jan 29, 2017·Acta Neuropathologica·Jiaying ZengWeihong Song
Aug 18, 2020·Expert Opinion on Drug Metabolism & Toxicology·Jason Nicol ClarkPeter McCaffery
Feb 21, 2014·Metabolic Brain Disease·Liliana LetraRaquel Seiça
Apr 14, 2020·European Journal of Medicinal Chemistry·Thanigaimalai PillaiyarMurugesan Sankaranarayanan
Oct 11, 2011·Journal of Cell Science·Tomonobu SatoShigetsugu Hatakeyama
Jun 17, 2008·Progress in Neurobiology·Sabien van NeervenJörg Mey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.