Retinoic acid receptor alpha expression and cutaneous ageing

Mechanisms of Ageing and Development
Rachel E B WatsonChristopher E M Griffiths

Abstract

Intrinsic ageing of human skin is a subtle and gradual process that demonstrates few clinical or histological features until old age (>70 years). Initial work indicates that aged skin is "retinoid sensitive" but there is little data on the role of retinoic acid receptors (RARs) or retinoid X receptors (RXRs) in skin ageing. As nuclear retinoid receptors have been implicated in ageing in rodents, we studied the distribution of these receptors in intrinsically aged as compared to young, photoprotected human skin. We found that intrinsic ageing of skin in vivo is accompanied by significant increases of RAR alpha mRNA and protein whereas other isoforms show no alteration with age. In vitro transfection of COS-1 cells with the RAR alpha gene induces expression of matrix metalloproteinase-1 (MMP-1), an enzyme known to play an active role in remodelling of the dermis in intrinsically aged and photoaged skin. Furthermore, addition of all-trans retinoic acid (RA) to cultures of RAR alpha-transfected COS-1 cells diminishes RAR alpha and returns levels of MMP-1 to those approaching baseline. These results demonstrate that intrinsic ageing of human skin is accompanied by significant elevation in the content of RAR alpha and that over-expre...Continue Reading

Citations

Dec 14, 2007·Free Radical Research·Rodrigo J S DalmolinJosé C F Moreira
Mar 20, 2009·Connective Tissue Research·Miklós Sárdy
Sep 16, 2011·Kidney International·Keng Thye WooChoong Meng Chan
Oct 4, 2006·Dermatologic Therapy·Minal Singh, Christopher E M Griffiths
Jan 10, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·A ChansonP Brachet
Apr 18, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Gustavo DieamantLuiz Claudio Di Stasi
May 21, 2008·International Journal of Cosmetic Science·M FarwickC E M Griffiths
Dec 12, 2007·The British Journal of Dermatology·R E B WatsonC E M Griffiths
May 15, 2009·The British Journal of Dermatology·R E B WatsonC E M Griffiths
Apr 9, 2010·Pigment Cell & Melanoma Research·Jun FanRichard M Niles

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