PMID: 15227730Jul 1, 2004Paper

Retinoic acid receptor-beta expression in stage I non-small cell lung cancer and adjacent normal appearing bronchial epithelium

Yonsei Medical Journal
Yoon Soo ChangSe Kyu Kim

Abstract

Retinoic acid receptor-beta (RAR-beta) is induced by and mediates the growth-inhibitory and apoptotic effects of retinoic acid (RA), suggesting that loss of RAR-beta expression may be one of the critical events involved in the carcinogenesis/ progression of non-small cell lung cancer (NSCLC) and in the responsiveness to retinoid chemotherapy. However, recent contradictory reports that the expression of RAR-beta is associated with poor clinical outcome, and the fact that treatment of serum-deprived type 2 alveolar cells with RA leads to a stimulation of cell proliferation, require the verification of RAR-beta as a biomarker of chemoprevention or prognosis. The expression status of RAR-beta in cancer cells and adjacent normal appearing bronchial epithelium from 39 patients, diagnosed as stage I NSCLC and undergone a curative lung resection, was analyzed in paraffin-embedded tissue sections by IHC staining. The normal appearing bronchial epithelium of 14 out of 33 (42.4%) specimens expressed RAR-beta, whereas 22 out of the 39 (56.4%) stage I NSCLC specimens expressed RAR-beta. RAR-beta was more frequently expressed in the adenocarcinoma (72.7%) than in the squamous cell carcinoma (31.3%) (p=0.026). Neither the expression status in...Continue Reading

Citations

Jan 28, 2014·Journal of Chemical Information and Modeling·Yongmei PanStephen H Bryant
Feb 6, 2007·Fertility and Sterility·William H Catherino, Minnie Malik
Oct 2, 2012·International Immunopharmacology· Siddikuzzaman, V M Berlin Grace
Jul 31, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Eva CsatlósGábor József Joó
Mar 25, 2016·PloS One·Agnieszka Anna CzajkaKrystian Jażdżewski
Jul 30, 2005·Ophthalmic Plastic and Reconstructive Surgery·Nitin ChakravartiBita Esmaeli

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