Retinoic acid receptor beta promoter methylation and risk of cervical cancer

World Journal of Virology
Chaninya WongwarangkanaYong Poovorawan

Abstract

Cervical cancer is one of the leading causes of death in women worldwide, particularly in developing countries. Human papillomavirus has been reported as one of the key etiologic factors in cervical carcinoma. Likewise, epigenetic aberrations have ability to regulate cancer pathogenesis and progression. Recent research suggested that methylation has been detected already at precancerous stages, which methylation markers may have significant value in cervical cancer screening. The retinoic acid receptor beta (RARβ) gene, a potential tumor suppressor gene, is usually expressed in normal epithelial tissue. Methylation of CpG islands in the promoter region of theRARβ gene has been found to be associated with the development of cervical cancer. To investigate whetherRARβ methylation is a potential biomarker that predicts the progression of invasive cancer, we reviewed 14 previously published articles related toRARβ methylation. The majority of them demonstrated that the frequency ofRARβ promoter methylation was significantly correlated with the severity of cervical epithelium abnormalities. However, methylation of a single gene may not represent the best approach for predicting disease prognosis. Analyzing combinations of aberrant m...Continue Reading

References

Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M Lusky, E Fontane
Jun 4, 2002·Nature Reviews. Genetics·Peter A Jones, Stephen B Baylin
Aug 28, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·G Sanclemente, D K Gill
Feb 7, 2003·The New England Journal of Medicine·Nubia MuñozUNKNOWN International Agency for Research on Cancer Multicenter Cervical Cancer Study Group
Feb 17, 2005·Journal of the National Cancer Institute·Qinghua FengNancy B Kiviat
Dec 7, 2005·International Journal of Cancer. Journal International Du Cancer·Hans-Ulrich BernardS Terence Dunn
May 25, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Zhi-Ming Zheng, Carl C Baker
Jun 1, 2006·International Journal of Cancer. Journal International Du Cancer·G Bea A WismanAte G J van der Zee
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Qinghua FengNancy B Kiviat
Jan 1, 2008·Obstetrics and Gynecology·Marc ArbynJohan Bulten
Sep 16, 2009·Carcinogenesis·Shikhar SharmaPeter A Jones
Mar 9, 2010·Cellular Oncology : the Official Journal of the International Society for Cellular Oncology·Nan YangAte G J van der Zee
May 6, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Tien-Hung HuangTang-Yuan Chu
May 25, 2010·Virchows Archiv : an International Journal of Pathology·Jo-Heon KimSaraswati Sukumar
Sep 9, 2010·Methods in Molecular Biology·Qing Yan
Jun 28, 2011·International Journal of Cancer. Journal International Du Cancer·Martyn PlummerUNKNOWN International Collaboration of Epidemiological Studies of Cervical Cancer
Jun 29, 2011·Therapeutic Delivery·Barbara MaT C Wu
Jun 26, 2012·Molecular and Cellular Biochemistry·Sujata PathakNeeta Singh
Sep 4, 2012·Clinical Epigenetics·Kathleen P SaavedraJuan Carlos S Roa
Sep 5, 2012·Nature Reviews. Genetics·Holger Heyn, Manel Esteller
Sep 11, 2012·International Journal of Cancer. Journal International Du Cancer·Anne F RositchJennifer S Smith
Oct 30, 2012·Genomics & Informatics·Eun Pyo Hong, Ji Wan Park
Dec 5, 2012·Vaccine·Lauri E MarkowitzJulia M L Brotherton
Mar 14, 2013·Journal of the National Cancer Institute·Dan ChenUlf Gyllensten
Mar 1, 2012·Cancer Biology & Medicine·Mei-Ying WengShun-Jia Hong
May 22, 2013·Cancer Biology & Medicine·Mei-Ying WengShu-Ying Feng
Jan 7, 2014·Nature·Akinyemi I OjesinaMatthew Meyerson
Feb 21, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jinchuan FangSufang Jin
Dec 4, 2014·Trends in Genetics : TIG·Dan Chen, Ulf Gyllensten
Dec 18, 2015·World Journal of Clinical Oncology·Rosa CatarinoPierre Vassilakos
Aug 22, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Fernanda Viviane MarianoAlbina Altemani

❮ Previous
Next ❯

Methods Mentioned

BETA
scrapings
biopsy
PCR

Software Mentioned

GLOBOSCAN

Related Concepts

Related Feeds

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.