Retinoic acid receptor-related orphan receptor alpha as a therapeutic target in the treatment of dyslipidemia and atherosclerosis

Drug News & Perspectives
Heidelinde JakelJean-Charles Fruchart

Abstract

Retinoic acid receptor-related orphan receptor alpha (RORalpha) is a member of the nuclear receptor family. Recently, cholesterol (derivatives) has been identified as an RORalpha ligand and deorphanized this receptor. RORalpha is expressed in many tissues and is therefore a regulator of multiple biological processes. Studies of staggerer mice and in vitro assays indicate a beneficial modulatory role of RORalpha in the pathogenesis of dyslipidemia, inflammation and atherosclerosis. This paper provides an overview on the role of RORalpha in lipid metabolism and discusses its potential therapeutic option for treating lipid and inflammatory disorders leading to atherosclerosis.

Citations

Nov 12, 2010·The Journal of Biological Chemistry·X Edward ZhouH Eric Xu
Nov 27, 2007·Gene Expression Patterns : GEP·Pellegrino RossiRaffaele Geremia
Feb 7, 2008·Fundamental & Clinical Pharmacology·Yves Landry, Jean-Pierre Gies
Mar 23, 2017·Pharmacology & Therapeutics·Fei LiFrank J Gonzalez
Nov 1, 2007·The Journal of Biological Chemistry·Dujin ZhouShiuan Chen
Jul 1, 2007·Expert Review of Endocrinology & Metabolism·Joana D AmaralCecília P Rodrigues
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haozhen MaFang Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.