Retinoic acid regulates cell-shape and -death of E-FABP (FABP5)-immunoreactive septoclasts in the growth plate cartilage of mice

Histochemistry and Cell Biology
Yasuhiko BandoOsamu Amano

Abstract

Septoclasts, which are mononuclear and spindle-shaped cells with many processes, have been considered to resorb the transverse septa of the growth plate (GP) cartilage at the chondro-osseous junction (COJ). We previously reported the expression of epidermal-type fatty acid-binding protein (E-FABP, FABP5) and localization of peroxisome proliferator-activated receptor (PPAR)β/δ, which mediates the cell survival or proliferation, in septoclasts. On the other hand, retinoic acid (RA) can bind to E-FABP and is stored abundantly in the GP cartilage. From these information, it is possible to hypothesize that RA in the GP is incorporated into septoclasts during the cartilage resorption and regulates the growth and/or death of septoclasts. To clarify the mechanism of the cartilage resorption induced by RA, we administered an overdose of RA or its precursor vitamin A (VA)-deficient diet to young mice. In mice of both RA excess and VA deficiency, septoclasts decreased in the number and cell size in association with shorter and lesser processes than those in normal mice, suggesting a substantial suppression of resorption by septoclasts in the GP cartilage. Lack of PPARβ/δ-expression, TUNEL reaction, RA receptor (RAR)β, and cellular retinoi...Continue Reading

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Citations

Feb 22, 2018·Histochemistry and Cell Biology·Yasuhiko BandoOsamu Amano
Nov 30, 2018·Molecular Biology of the Cell·David MelvilleRandy Schekman
Jul 20, 2017·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth
Nov 25, 2019·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth
Jan 6, 2021·Histochemistry and Cell Biology·Yasuhiko BandoOsamu Amano
Apr 14, 2021·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth

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