Retinoic acid regulates insulin-like growth factor-binding protein expression in human osteoblast cells

Endocrinology
Y ZhouD D Strong

Abstract

Retinoic acid (RA) regulates the growth and differentiation of numerous cells types and plays a key role in skeletal development. Previous studies have demonstrated that insulin-like growth factors (IGFs) are important local regulators of bone cell proliferation and differentiation and that IGF-binding proteins (IGFBPs) modulate their activities. In an attempt to test the hypothesis that RA mediates its effects on bone cells in part by regulating IGFBP expression, we first examined the effect of RA on IGFBP expression in human osteoblast model systems and then compared these responses to the effects of RA on IGFBP expression in human skin fibroblasts. The most dramatic effect of RA on IGFBPs++ in all cell types tested was to increase IGFBP-6 messenger RNA (mRNA) abundance more than 1000% of the control value. Significant effects on IGFBP-5 mRNA abundance were also found, with maximal reductions to 35% of control within 24 h of treatment. In addition, RNA maximally increased IGFBP-3 and -4 mRNA to 580% and 390% of the control value, respectively, in SaOS-2 cells, but had variable effects on IGFBP-3 and -4 mRNA levels in human bone cells, U2-OS, and human skin fibroblasts. The levels of the 24-, 29- to 32-, and 38- to 42 kDa IGFB...Continue Reading

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