Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2.

Developmental Biology
Sandeep Kumar, Gregg Duester

Abstract

Morphogenesis during eye development requires retinoic acid (RA) receptors plus RA-synthesizing enzymes, and loss of RA signaling leads to ocular disorders associated with loss of Pitx2 expression in perioptic mesenchyme. Several Wnt signaling components are expressed in ocular tissues during eye development including Dkk2, encoding an inhibitor of Wnt/beta-catenin signaling, which was previously shown to be induced by Pitx2 in the perioptic mesenchyme. Here, we investigated potential cross-talk between RA and Wnt signaling during ocular development. Genetic studies using Raldh1/Raldh3 double null mice deficient for ocular RA synthesis demonstrated that Pitx2 and Dkk2 were both down-regulated in perioptic mesenchyme. Chromatin immunoprecipitation and gel mobility shift studies demonstrated the existence of a DR5 RA response element upstream of Pitx2 that binds all three RA receptors in embryonic eye. Axin2, an endogenous readout of Wnt/beta-catenin signaling, was up-regulated in cornea and perioptic mesenchyme of RA deficient embryos. Also, expression of Wnt5a was expanded in perioptic mesenchyme of RA deficient eyes. Our findings demonstrate excessive activation of Wnt signaling in the perioptic mesenchyme of RA deficient mice...Continue Reading

References

Jan 1, 1993·Methods in Enzymology·D G Wilkinson, M A Nieto
Feb 1, 1997·Developmental Biology·D C SlusarskiR T Moon
Sep 24, 1999·Mechanisms of Development·A P MonaghanC Niehrs
May 24, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T A HjaltJ C Murray
Jan 16, 2003·Gene·Bingyu Mao, Christof Niehrs
Jun 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Felix A MicGregg Duester
Jun 20, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hong LiuValerie A Wallace
Sep 15, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Felix A MicGregg Duester
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse
Nov 24, 2004·The International Journal of Developmental Biology·Douglas B GouldSimon W M John
Aug 6, 2005·The Journal of Steroid Biochemistry and Molecular Biology·J E Balmer, R Blomhoff
Oct 7, 2005·Development·Nicolas MattNorbert B Ghyselinck
Oct 27, 2005·Investigative Ophthalmology & Visual Science·Philip J GageTord Hjalt
Apr 11, 2006·Molecular Reproduction and Development·Cheryl EifertPaulette J McCormick
Aug 29, 2006·Investigative Ophthalmology & Visual Science·Nicole WeisschuhEugen Gramer
Nov 6, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Cheng-Ji ZhouYa-Zhou Wang
Jan 6, 2009·Organogenesis·Sabine Fuhrmann
Jun 19, 2009·Nature Reviews. Molecular Cell Biology·Stephane Angers, Randall T Moon
Jun 23, 2009·Gene Expression Patterns : GEP·Xianling Zhao, Gregg Duester

❮ Previous
Next ❯

Citations

Mar 28, 2013·Journal of Ophthalmology·Shivalingappa K Swamynathan
Sep 4, 2014·Human Genetics·Eric WehElena V Semina
May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Giuseppe LupoStephen W Wilson
Oct 12, 2012·Glycoconjugate Journal·Leyla GasimliRobert J Linhardt
Aug 13, 2010·Biomarkers in Medicine·Rudolf NapieralskiManfred Schmitt
Aug 10, 2013·Bioinformatics·Alexis AllotOdile Lecompte
Jun 23, 2011·Seminars in Cell & Developmental Biology·Juliana Gutierrez-MazariegosMichael Schubert
Jan 22, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elodie CollombDanielle Dhouailly
Oct 21, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Amanda L Zacharias, Philip J Gage
Apr 24, 2013·Evolution & Development·Stephanie BloomNanette Nascone-Yoder
Feb 11, 2011·Genesis : the Journal of Genetics and Development·Phillip E KishAlon Kahana
Aug 19, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Danielle DhouaillyFrederic Michon
Sep 25, 2014·Developmental Biology·Joanne G A SavoryDavid Lohnes
Sep 23, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chenqi Tao, Xin Zhang
Jun 6, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Antionette L Williams, Brenda L Bohnsack
Apr 26, 2011·Biochimica Et Biophysica Acta·Sandeep KumarGregg Duester
Aug 17, 2010·Developmental Biology·H ThompsonI M McGonnell
May 5, 2011·Developmental Biology·Oliver Lieven, Ulrich Rüther
May 14, 2016·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Bahaar ChawlaBrenda L Bohnsack
Feb 6, 2014·PloS One·Qinghang MengYing Xia
Jul 28, 2016·Science Signaling·Junning YangArie Horowitz
Jan 19, 2012·Nutrients·Margaret Clagett-Dame, Danielle Knutson
Jan 7, 2015·Nature Reviews. Molecular Cell Biology·Thomas J Cunningham, Gregg Duester
Feb 2, 2018·Cellular and Molecular Life Sciences : CMLS·Elisabeth ZiegerMichael Schubert
Feb 27, 2017·Disease Models & Mechanisms·Mao MaoDouglas B Gould
Jun 4, 2019·Genesis : the Journal of Genetics and Development·Antionette L Williams, Brenda L Bohnsack
Apr 21, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Tamara Anne Franz-Odendaal
Sep 4, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pawat SeritrakulWilliam R Jackman
Feb 21, 2019·Investigative Ophthalmology & Visual Science·Justin Ma, Peter Lwigale
Aug 25, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ségolène Bernheim, Sigolène M Meilhac
Jul 6, 2019·Development·Norbert B Ghyselinck, Gregg Duester
Jan 12, 2021·Frontiers in Cell and Developmental Biology·Antionette L Williams, Brenda L Bohnsack
Feb 12, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hannah FlachSusanne J Kühl
Jul 9, 2021·Progress in Retinal and Eye Research·Pere CatalàMor M Dickman
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Qi WangHiroshi Kurosaka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.