PMID: 19943455Dec 1, 2009Paper

Retinoic acid stimulate differentiation of hippocampal stem cells into opsin expressing cells in vitro

Pakistan Journal of Biological Sciences : PJBS
M SafariM T Joghataee

Abstract

The results of several studies have demonstrated that cell differentiation influenced by derivatives of retinoic acid. To determine whether retinoic acid mediate the differentiation of neural stem cells we treated dissociated hippocampal stem cells with different concentrations of all trans or 9-cis retinoic acid and analyzed the effects on cell fate by specific monoclonal antibody for photoreceptors. Addition of exogenous retinoic acid caused a dose dependent specific in the elevation of the cell number that developed as photoreceptors in culture. Also results ofimmunohistochemical studies using monoclonal antibody demonstrated that the primary effect ofretinoic acid was to influence progenitor cells the developed as mature and immature photoreceptors. These results suggest that retinoic acid may play an important effect in the normal development of photoreceptor cells in vitro.

Citations

Feb 15, 2011·Pakistan Journal of Biological Sciences : PJBS·M Safari

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