PMID: 9193722Jun 1, 1997Paper

Retinoid binding proteins in mouse yolk sac and chorio-allantoic placentas

Anatomy and Embryology
S JohanssonL Dencker

Abstract

In the adult, as well as in the embryo, a number of specific extra- and intracellular binding proteins such as the plasma retinol binding protein (RBP), the cellular retinol binding protein type I (CRBP I), and also the cellular receptors for RBP are thought to regulate transport and metabolism of retinol (vitamin A). Since the regulation of materno-fetal transport of vitamin A is not well understood, we examined the localization of these proteins during the development of the mouse chorio-allantoic and yolk sac placentas. The labyrinthine region of the chorio-allantoic placenta, where exchange of substances can occur between the maternal and fetal circulations, did not contain RBP (mRNA or protein) or antigen(s) similar to the bovine RBP-receptor p63, whereas the visceral endoderm of the yolk sac placenta, the second site for materno-fetal transport, did. Furthermore, only the endodermal cells of the visceral yolk sac appeared to strongly accumulate radiolabelled retinoids. The cellular retinol binding protein (CRBP I) was detected both in the trophoblast layer of the placental labyrinth closest to the fetal endothelium (layer III), and in the visceral endoderm of the yolk sac. Together, these findings suggest that the yolk sa...Continue Reading

Citations

Jun 25, 2010·The Journal of Biological Chemistry·Takahiko KogaiGregory A Brent
Jun 11, 2002·Annual Review of Nutrition·Margaret Clagett-Dame, Hector F DeLuca
Mar 15, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nicolas MattNorbert B Ghyselinck
Nov 6, 2008·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Claudia Freyer, Marilyn B Renfree
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Richard J White, Thomas F Schilling
Mar 21, 2007·Vitamins and Hormones·Geoffroy MarceauVincent Sapin
Mar 5, 2014·Journal of Agricultural and Food Chemistry·Sophie Réhault-GodbertYves Nys
May 9, 2000·The American Journal of Clinical Nutrition·V Azaïs-Braesco, G Pascal
Feb 23, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ryann M FameHazel L Sive
Apr 15, 1999·Journal of the American Society of Nephrology : JASN·E I ChristensenS K Moestrup
Jul 30, 2020·Nature Communications·Connor Ross, Thorsten E Boroviak
Aug 18, 2021·ELife·Kirsty Ml MackinlayMagdalena Zernicka-Goetz

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