PMID: 6942700Feb 27, 1981Paper

Retinoid-binding proteins in plasma and in cells

Annals of the New York Academy of Sciences
D S Goodman

Abstract

Much has been learned during the past decade about the specific retinoid-binding proteins that exist in plasma, and in the intracellular compartment in a number of tissues. Vitamin A is mobilized from liver stores and transported in plasma in the form of the lipid alcohol retinol, bound to a specific transport protein, retinol-binding protein (RBP). A great deal is now known about the chemical structure, metabolism, and biological roles of RBP. Vitamin A mobilization from the liver is highly regulated by factors that control the rates of RBP production and secretion. Retinol deficiency specifically blocks the secretion of RBP, which can then be rapidly stimulated by intravenous retinol repletion. The cellular and molecular mechanisms that mediate these phenomena are under investigation. Delivery of retinol to peripheral tissues appears to involve specific cell surface receptors for RBP. The retinol so delivered enters the target cell, where it may become associated with the intracellular binding protein for retinol (CRBP). A number of tissues of rats, humans, and other species contain soluble proteins with binding specificity for retinol (CRBP) or for retinoic acid (CRABP). These proteins have been purified from several tissues...Continue Reading

References

Aug 1, 1978·The Biochemical Journal·B P Sani, C K Banerjee
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S TakaseF Chytil
Aug 1, 1979·FEBS Letters·L RaskP A Peterson
Apr 8, 1976·The New England Journal of Medicine·F R Smith, D S Goodman
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M M BashorF Chytil
Jan 1, 1974·Vitamins and Hormones·D S Goodman
Jul 21, 1972·Biochimica Et Biophysica Acta·A M GottoD S Goodman
Nov 1, 1971·The Journal of Clinical Investigation·F R Smith, D S Goodman
Sep 1, 1968·The Journal of Clinical Investigation·M KanaiD S Goodman

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Citations

Dec 1, 1981·Journal of Steroid Biochemistry·G Pérez-PalaciosA E Pérez
Jul 25, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lara HookerMichael J Crawford
Apr 13, 1982·Biochemistry·M A Gawinowicz, D S Goodman
Mar 15, 1989·Physical Review. D·I H Russell, D J Toms
Feb 27, 1981·Annals of the New York Academy of Sciences·J E SmithD S Goodman
Mar 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Chytil

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