PMID: 6942700Feb 27, 1981Paper

Retinoid-binding proteins in plasma and in cells

Annals of the New York Academy of Sciences
D S Goodman


Much has been learned during the past decade about the specific retinoid-binding proteins that exist in plasma, and in the intracellular compartment in a number of tissues. Vitamin A is mobilized from liver stores and transported in plasma in the form of the lipid alcohol retinol, bound to a specific transport protein, retinol-binding protein (RBP). A great deal is now known about the chemical structure, metabolism, and biological roles of RBP. Vitamin A mobilization from the liver is highly regulated by factors that control the rates of RBP production and secretion. Retinol deficiency specifically blocks the secretion of RBP, which can then be rapidly stimulated by intravenous retinol repletion. The cellular and molecular mechanisms that mediate these phenomena are under investigation. Delivery of retinol to peripheral tissues appears to involve specific cell surface receptors for RBP. The retinol so delivered enters the target cell, where it may become associated with the intracellular binding protein for retinol (CRBP). A number of tissues of rats, humans, and other species contain soluble proteins with binding specificity for retinol (CRBP) or for retinoic acid (CRABP). These proteins have been purified from several tissues...Continue Reading


Aug 1, 1978·The Biochemical Journal·B P Sani, C K Banerjee
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S TakaseF Chytil
Aug 1, 1979·FEBS Letters·L RaskP A Peterson
Apr 8, 1976·The New England Journal of Medicine·F R Smith, D S Goodman
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M M BashorF Chytil
Jan 1, 1974·Vitamins and Hormones·D S Goodman
Jul 21, 1972·Biochimica Et Biophysica Acta·A M GottoD S Goodman
Nov 1, 1971·The Journal of Clinical Investigation·F R Smith, D S Goodman
Sep 1, 1968·The Journal of Clinical Investigation·M KanaiD S Goodman

❮ Previous
Next ❯


Dec 1, 1981·Journal of Steroid Biochemistry·G Pérez-PalaciosA E Pérez
Jul 25, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lara HookerMichael J Crawford
Apr 13, 1982·Biochemistry·M A Gawinowicz, D S Goodman
Mar 15, 1989·Physical Review. D·I H Russell, D J Toms
Feb 27, 1981·Annals of the New York Academy of Sciences·J E SmithD S Goodman
Mar 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Chytil

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.