PMID: 3319727Jan 1, 1987Paper

Retinoid effects on the epidermis

Dermatologica
Peter M Elias

Abstract

Since metaplasia and gap junction stimulation are prominent features of retinoid activity in embryonic and neoplastic epidermis, it is ironic that the mechanism(s) of retinoid action in postnatal tissues, where these drugs are employed clinically, appears to be different. Histologic studies in both animals and man with both topical and systemic retinoids demonstrate acanthosis, hypergranulosis, and changes in the thickness and organization of the stratum corneum, due to a boost in cell turnover. On an ultrastructural level, desmosomes are actively shed at the level of the spinous layer, leading to many new attachment points along the cell membranes of the outer epidermis. This change coupled with decreased tonofilaments, enhanced keratinocyte autolysis, and intercellular deposition of glycoconjugates (not mucin by standard histochemistry and lectin binding) lead to loosening and fragility of the stratum corneum. The biochemical basis of retinoid activity (in addition to increased cell turnover) appears to be global enhancement of glycoconjugate synthesis and the generation of less mature keratins. These epidermal effects of retinoids can be exploited therapeutically: (1) to cause loosening of thickened stratum corneum, e.g., in...Continue Reading

Citations

Jan 17, 2004·Journal of the American Academy of Dermatology·Jürgen V SmitElke M G J de Jong
Mar 1, 1993·The Journal of Dermatologic Surgery and Oncology·S BrennerD I Dascalu
Aug 23, 2016·Expert Opinion on Orphan Drugs·William B Rizzo
Jan 20, 1999·The British Journal of Dermatology·R O BredlichR U Peter
Jul 1, 1993·Clinical and Experimental Dermatology·E M Higgins, A C Pembroke
Oct 1, 1992·The British Journal of Dermatology·C C ZouboulisC E Orfanos
Mar 18, 2011·Experimental Dermatology·Johanna MihályRalph Rühl
Aug 10, 2016·Cellular and Molecular Life Sciences : CMLS·Aurélie ComptourVincent Sapin
May 6, 2021·International Journal of Dermatology·Sinan Özçelik, Fatma A Kılıç

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