PMID: 2126091Nov 1, 1990Paper

Retinoid-induced ear malformations

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
G Granström

Abstract

Treatment of pregnant Sprague-Dawley rats with retinoic acid or etretinate pregnancy day 8.5 to 9.0 resulted in craniofacial defects in 100% of the embryos. A morphologic investigation of the malformations occurring in the ear was performed. Outer ears were missing, microtic, low-placed, and dorsally situated. External acoustic meatus was short or absent. Middle ear structures were delayed in differentiation, middle ear ossicle primordia were hypoplastic and malformed, the stapedial artery and facial nerve were hypoplastic, and their relation to the stapes was variable. In the inner ear, the otic capsule was thick, the cochlea had fewer turns and the semicircular ducts showed poor differentiation.

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Jan 1, 1990·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·G Granström, A Kullaa-Mikkonen
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Citations

Jun 1, 1997·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·C Jacobsson, G Granström
Mar 31, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Sydney C ButtsDorothy A Frenz
Nov 26, 2010·American Journal of Medical Genetics. Part a·Dorothy A FrenzAlan Shanske
Apr 17, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Wei LiuDorothy A Frenz
Jan 1, 1992·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·G GranströmS Kirkeby
Jan 1, 1991·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·G GranströmB C Magnusson
Dec 5, 2002·Mechanisms of Development·Raymond RomandNorbert B Ghyselinck
Jul 29, 1999·The Journal of Prosthetic Dentistry·R R Wang, C J Andres

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