PMID: 8937896Nov 1, 1996Paper

Retinoid-induced epiphyseal plate closure in guinea pigs

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
A M StandevenV A Thomazy

Abstract

Vitamin A and its derivatives (retinoids) have been known to cause premature epiphyseal closure in humans as an unwanted side effect of chronic treatment. The purpose of the present study was to determine if guinea pigs could serve as an animal model of retinoid-induced epiphyseal plate closure, and to utilize this model to study the mechanism. Weanling male Hartley guinea pigs were treated ip via osmotic pump for up to 14 days with vehicle or 0.50 to 5.5 mg/kg/day of the retinoic acid receptor (RAR)-selective agonist AGN 190121. Histopathological examination of the proximal tibia of AGN 190121-treated guinea pigs revealed a dose-dependent disruption of the epiphyseal plate. The natural retinoids all-trans-retinoic acid and 13-cis-retinoic acid also induced epiphyseal plate closure in guinea pigs when administered by ip injection for 10 days. Prominent histological features of retinoid-induced epiphyseal closure included the loss of basophilic staining in the extracellular matrix of epiphyseal plate chondrocytes and the invasion of the epiphyseal plate by osteoclasts. To determine if the epiphyseal closure detected histologically was reversible, guinea pigs were treated for 6 days with the RAR-selective agonist (E)-4[2-(5,6,7,8...Continue Reading

Citations

Jul 13, 2001·Antiviral Research·R G JainJ M Lenhard
Jul 20, 1999·Molecular and Cellular Endocrinology·D A Stevens, G R Williams
Aug 28, 1999·Bioorganic & Medicinal Chemistry·A T JohnsonR A Chandraratna
Mar 24, 2007·Biochemistry·Alexander R MoiseWilliam S Blaner
Jun 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·M WeiseJ Baron
Dec 14, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·François LuthiNicolas Theumann
Feb 12, 2005·Respiratory Physiology & Neurobiology·Cuneyt YilmazConnie C W Hsia
Oct 12, 2014·Biochemical and Biophysical Research Communications·Yoshiki MinegishiNoriyuki Tsumaki
Aug 31, 2000·Journal of Molecular Biology·B P KlaholzD Moras
Aug 19, 2016·Pediatric Blood & Cancer·Sogol Mostoufi-Moab
Aug 18, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nicholas A MignemiJonathan G Schoenecker
Sep 14, 2016·Journal of Toxicologic Pathology·Stacey FosseyJoel Leininger
Feb 21, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Salin A ChakkalakalEileen M Shore
Mar 18, 2015·Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society·Adam Domonkos TarnokiViktor Berczi
Nov 11, 2020·Pediatric Dermatology·Andrea L ZaengleinUNKNOWN PeDRA Use of Retinoids in Ichthyosis Work Group
Jun 30, 2021·Journal of Cachexia, Sarcopenia and Muscle·Michelle GuoSogol Mostoufi-Moab
Aug 12, 2021·The Journal of Dermatological Treatment·Haady Fallah, Marius Rademaker

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